Evidence map›Paper›PMID 32371554›Full record

ArticleLife science alliance2020

Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.

Parash Parajuli, Thien Ly Nguyen, Céline Prunier, Mohammed S Razzaque, Keli Xu, Azeddine Atfi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  20. TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma.Computational and structural biotechnology journal · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Parash ParajuliCellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Thien Ly NguyenCellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Céline PrunierSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France.
Mohammed S RazzaqueDepartment of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.ORCID 0000-0003-1115-4550
Keli XuCancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0001-5535-1076
Azeddine AtfiCellular and Molecular Pathogenesis Division, Department of Pathology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA azeddine.atfi@inserm.fr.ORCID 0000-0002-9986-3572
Inserm · FRVirginia Commonwealth University · USLake Erie College of Osteopathic Medicine · USUniversity of Mississippi Medical Center · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Targeting the TGIF/Twist1 network in osteosarcomaR01CA210911 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ATFI, AZEDDINE · 2017 to 2021
$1.8M
Role of TGIF in Wnt-Induced Bone FormationR01AR059070 · NIAMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI ATFI, AZEDDINE · 2010 to 2014
$1.7M
NCI NIH HHS R01 CA210911NIAMS NIH HHS R01 AR059070NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that remains incurable because of late diagnosis, which renders any therapeutic intervention challenging. Most PDAC patients develop de novo diabetes, which exacerbates their morbidity and mortality. How PDAC triggers diabetes is still unfolding. Using a mouse model of Kras

Indexed as

AnimalsAntibodies, NeutralizingApoptosisCarcinoma, Pancreatic DuctalCells, CulturedDiabetes MellitusDisease Models, AnimalDisease ProgressionGene DeletionInsulin-Secreting CellsMiceMice, Inbred C57BLMice, TransgenicPancreatic NeoplasmsPrognosisReceptor, Transforming Growth Factor-beta Type IIAntibodies, NeutralizingReceptor, Transforming Growth Factor-beta Type IISmad4 ProteinSmad4 protein, mouseTgfb1 protein, mouseTgfbr2 protein, mouseTransforming Growth Factor beta1

Identifiers

PMID32371554
PMCPMC7211975
OpenAlexW3021595174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.