Evidence map›Paper›PMID 32371548›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2020

Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor-producing Th1 cells in CNS neuroinflammation.

Farinaz Safavi, Rodolfo Thome, Zichen Li, Guang-Xian Zhang, Abdolmohamad Rostami

Open access · goldAbstract read
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. GM-CSFTheranostics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Farinaz SafaviFrom the Department of Neurology (F.S., R.T., Z.L., G.-X.Z., A.R.), Thomas Jefferson University, Philadelphia, PA. Dr. Safavi is now at National Institute of Health, NINDS, Bethesda, MD.
Rodolfo ThomeFrom the Department of Neurology (F.S., R.T., Z.L., G.-X.Z., A.R.), Thomas Jefferson University, Philadelphia, PA. Dr. Safavi is now at National Institute of Health, NINDS, Bethesda, MD.
Zichen LiFrom the Department of Neurology (F.S., R.T., Z.L., G.-X.Z., A.R.), Thomas Jefferson University, Philadelphia, PA. Dr. Safavi is now at National Institute of Health, NINDS, Bethesda, MD.
Guang-Xian ZhangFrom the Department of Neurology (F.S., R.T., Z.L., G.-X.Z., A.R.), Thomas Jefferson University, Philadelphia, PA. Dr. Safavi is now at National Institute of Health, NINDS, Bethesda, MD.
Abdolmohamad RostamiFrom the Department of Neurology (F.S., R.T., Z.L., G.-X.Z., A.R.), Thomas Jefferson University, Philadelphia, PA. Dr. Safavi is now at National Institute of Health, NINDS, Bethesda, MD. a.m.rostami@jefferson.edu.
Thomas Jefferson University · US

Funding

The role of IL-27 in iv tolerance in EAER01AI106026 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2014 to 2018
$1.9M
The Role of GM-CSF in the Pathogenesis of Multiple SclerosisR01NS088729 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2014 to 2018
$1.7M
NIAID NIH HHS R01 AI106026NINDS NIH HHS R01 NS088729
6 · The paper itself

Abstract

objectiveTo study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4

methodsWe collected splenocytes and CD4

resultsDF acts directly on CD4

conclusionsWe suggest that DF exclusively suppresses GM-CSF-producing Th1 cells in both animal and human CD4

Indexed as

AdultAnimalsCD4-Positive T-LymphocytesDimethyl FumarateEncephalomyelitis, Autoimmune, ExperimentalFemaleGranulocytesHumansImmunologic FactorsInterferon-gammaMacrophage Colony-Stimulating FactorMiceMice, Inbred C57BLSignal TransductionTh1 CellsDimethyl FumarateImmunologic FactorsInterferon-gammaMacrophage Colony-Stimulating Factor

Identifiers

PMID32371548
PMCPMC7217662
OpenAlexW3021993019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.