ArticleBMJ open2020
Prevalence of secondary care multimorbidity in mid-life and its association with premature mortality in a large longitudinal cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Effectiveness and Experiences of Self-Management Interventions in Adults With Multiple Long-Term Conditions: A Mixed Methods Systematic Review.Journal of evaluation in clinical practice · 2026Pooled it
- The Impact of a Health Coaching App on the Subjective Well-Being of Individuals With Multimorbidity: Mixed Methods Study.Journal of medical Internet research · 2026Article
- Multiple Maternal Chronic Conditions and Risk of Severe Neonatal Morbidity and Mortality.JAMA network open · 2026Article
- Multiple Chronic Conditions Before Pregnancy and Risk of Adverse Maternal Health Outcomes: Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Experiences of Social Relationships for Adults Living With Multiple Long-Term Conditions: A Qualitative Interview Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Multimorbidity in tuberculosis (TB) and its impact on patient care (MITICare): a cross-sectional study nested within a prospective cohort study protocol.Wellcome open research · 2025Article
- Clusters and associations of adverse neonatal events with adult risk of multimorbidity: A secondary analysis of birth cohort data.PloS one · 2025Article
- Multimorbidity in systemic lupus erythematosus in a population-based cohort: the Lupus Midwest Network.Rheumatology (Oxford, England) · 2024Article
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- Patterns and Predictors of Multimorbidity in the Azar Cohort.Archives of Iranian medicine · 2023Article
- Use of Drugs with Anticholinergic Properties at Hospital Admission Associated with Mortality in Older Patients: A Danish Nationwide Register-Based Cohort Study.Drugs - real world outcomes · 2022Article
- Association between number of medications and mortality in geriatric inpatients: a Danish nationwide register-based cohort study.European geriatric medicine · 2020Article
- Descriptions of advanced multimorbidity: A scoping review with content analysis.Journal of multimorbidity and comorbidityReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesMultimorbidity is the coexistence of two or more health conditions in an individual. Multimorbidity in younger adults is increasingly recognised as an important challenge. We assessed the prevalence of secondary care multimorbidity in mid-life and its association with premature mortality over 15 years of follow-up, in the Aberdeen Children of the 1950s (ACONF) cohort.
methodA prospective cohort study using linked electronic health and mortality records. Scottish ACONF participants were linked to their Scottish Morbidity Record hospital episode data and mortality records. Multimorbidity was defined as two or more conditions and was assessed using healthcare records in 2001 when the participants were aged between 45 and 51 years. The association between multimorbidity and mortality over 15 years of follow-up (to ages 60-66 years) was assessed using Cox proportional hazards regression. There was also adjustment for key covariates: age, gender, social class at birth, intelligence at age 7, secondary school type, educational attainment, alcohol, smoking, body mass index and adult social class.
resultsOf 9625 participants (51% males), 3% had multimorbidity. The death rate per 1000 person-years was 28.4 (95% CI 23.2 to 34.8) in those with multimorbidity and 5.7 (95% CI 5.3 to 6.1) in those without. In relation to the reference group of those with no multimorbidity, those with multimorbidity had a mortality HR of 4.5 (95% CI 3.4 to 6.0) over 15 years and this association remained when fully adjusted for the covariates (HR 2.5 (95% CI 1.5 to 4.0)).
conclusionMultimorbidity prevalence was 3% in mid-life when measured using secondary care administrative data. Multimorbidity in mid-life was associated with premature mortality.
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