Evidence map›Paper›PMID 32371394›Full record

ArticleThe Journal of biological chemistry2020

Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants.

Kelsey S Kalous, Sarah L Wynia-Smith, Steven B Summers, Brian C Smith

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Tubulin Acetylation and the Cellular Mechanosensing and Stress Response.Results and problems in cell differentiation · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Nitro-fatty acids as activators of hSIRT6 deacetylase activity.The Journal of biological chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelsey S KalousDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Sarah L Wynia-SmithDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Steven B SummersDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Brian C SmithDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA brismith@mcw.edu.ORCID 0000-0001-6330-2768
Medical College of Wisconsin · US

Funding

Biochemical mechanisms of beta cell protection through bromodomain inhibitionR01DK119359 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Brian Christopher Smith · 2018 to 2026
$3.1M
Sirt6 NAD+-Dependent Protein Deacetylase Inhibition by Cysteine S-nitrosationF31DK117588 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KALOUS, KELSEY SHEA · 2018 to 2020
$110k
American Heart Association-American Stroke Association 15SDG25830057NIDDK NIH HHS F31 DK117588NIDDK NIH HHS R01 DK119359
6 · The paper itself

Abstract

Sirtuins (

Indexed as

CysteineGlutathioneHumansKineticsMitochondriaNitric OxideOxidantsProtein Processing, Post-TranslationalRecombinant ProteinsSirtuin 1Sirtuin 2SirtuinsS-NitrosoglutathioneCysteineGlutathioneNitric OxideOxidantsRecombinant ProteinsSIRT6 protein, humanSirtuin 1Sirtuin 2SirtuinsS-Nitrosoglutathioneenzyme inactivationglutathionylationhydrogen peroxidenicotinamide adenine dinucleotide (NAD)nitric oxideprotein acylationreactive nitrogen species (RNS)redox signalingsirtuinS-nitrosylation

Identifiers

PMID32371394
PMCPMC7307208
OpenAlexW3022324258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.