ArticleEnvironmental research2020
Lagged WQS regression for mixtures with many components.
Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Household Air Pollution and Child Lung Function: The Ghana Randomized Air Pollution and Health Study.American journal of respiratory and critical care medicine · 2024Trial
- Prenatal Exposure to Ambient Air Pollution and Fetal Growth Trajectories in Wuhan, China.Environmental health perspectives · 2026Article
- Comparison of environmental mixture methods for estimating the joint effects of environmental mixtures.Environmental research · 2026Article
- Multi-model analysis of the combined toxic effects of ultrafine carbon black and amisulbrom on A549 Cells.Scientific reports · 2026Article
- Wqsreg: a Stata command for weighted quantile sum regression.European journal of epidemiology · 2026Article
- Workflow for Statistical Analysis of Environmental Mixtures.Environmental health perspectives · 2026Review
- Single versus mixed perfluorinated compound exposures and cardiovascular disease risk: mechanistic insights from cross-sectional data and molecular interactions.Archives of toxicology · 2026Article
- Fetal and postnatal metal metabolism-related changes in brain function are associated with childhood behavioral deficits.Science advances · 2026Article
- Critical windows and risk thresholds of prenatal mixed air pollutant exposure for oligohydramnios: Evidence from a population‑based study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Tracking COVID-19 vaccination barriers over time: a census-tract-level barrier index approach.Epidemiology and infection · 2026Article
- Metals and metal mixtures associated with the odds of uterine fibroid prevalence among African Caribbean women in the Tobago Health Study.Frontiers in reproductive health · 2026Article
- Article
- Associations of sleep, sedentary behavior, and physical activity during out-of-school time and the risk of overweight and obesity in children and adolescents: a dose-response and isotemporal substitution analysis.BMC public health · 2025Article
- LOW-RANK LONGITUDINAL FACTOR REGRESSION WITH APPLICATION TO CHEMICAL MIXTURES.The annals of applied statistics · 2025Article
- Unveiling Community Vulnerability to COVID-19 Incidence: A Population-Based Spatial Analysis in Clark County, Nevada.International journal of environmental research and public health · 2025Article
- Association between oxidative balance score and gallstone disease: a population-based study from NHANES.Frontiers in nutrition · 2025Article
- Environmental Mixtures Analysis (E-MIX) Workflow and Methods Repository.medRxiv : the preprint server for health sciences · 2024Article
- Association between Healthy Eating Index-2015 total and component food scores with reproductive lifespan among postmenopausal women: a population-based study from NHANES 2005-2016.BMC public health · 2024Article
- Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function.The Science of the total environment · 2024Article
- Combined Exposures and Mixtures Research: An Enduring NIEHS Priority.Environmental health perspectives · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The developmental timing of exposures to toxic chemicals or combinations of chemicals may be as important as the dosage itself. This concept is called "critical windows of exposure." The time boundaries of such windows can be detected if exposure data are collected repeatedly in short time intervals. The development of tooth-matrix biomarkers which provide prenatal and postnatal exposure measures in repeated intervals can provide such data. Using teeth, we use reverse distributed lagged models (DLMs) to incorporate weekly prenatal and postnatal measures of exposures to estimate time-varying associations with developmental effects. The analysis of such data using lagged weighted quantile sum (WQS) regression as an extension to reverse DLMs for complex mixtures was first proposed by Bello et al. This prior algorithm was not operationally generalizable to large numbers of components (say, more than five or six). We propose a revised algorithm that may be useful for larger mixtures by combining time-specific WQS(t) indices in a reverse DLM. We demonstrate the new algorithm using tooth data in association with a neurodevelopmental score and in simulated data from 3 cases wherein different components of a mixture have time varying associations and in the case where none have associations. The new algorithm correctly detects the simulated associations when the number of samples within the time-specific analyses is moderate to large.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.