Evidence map›Paper›PMID 32371201›Full record

ArticleJournal of neuroimmunology2020

Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy.

Beret Amundson, Lillin Lai, Mark J Mulligan, Yong Xu, Zidou Zheng, Suprateek Kundu, Jeffrey L Lennox, Drenna Waldrop-Valverde, Donald Franklin, Alison Swaims-Kohlmeier and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Cerebrospinal fluid CD14Journal of neurovirology · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Beret AmundsonEmory University School of Medicine, Atlanta, GA, USA.
Lillin LaiNew York University Vaccine Center and Department of Medicine, New York University School of Medicine, New York, NY, USA.
Mark J MulliganNew York University Vaccine Center and Department of Medicine, New York University School of Medicine, New York, NY, USA.
Yong XuEmory University School of Medicine, Atlanta, GA, USA.
Zidou ZhengDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Suprateek KunduDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Jeffrey L LennoxEmory University School of Medicine, Atlanta, GA, USA.
Drenna Waldrop-ValverdeEmory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.
Donald FranklinDepartment of Psychiatry, University of California at San Diego School of Medicine, La Jolla, CA, USA.
Alison Swaims-KohlmeierCenters for Disease Control and Prevention, Atlanta, GA, USA.
Scott L LetendreDepartment of Psychiatry, University of California at San Diego School of Medicine, La Jolla, CA, USA; gDepartment of Medicine, University of California at San Diego School of Medicine, La Jolla, CA, USA.
Albert M AndersonEmory University School of Medicine, Atlanta, GA, USA. Electronic address: aande2@emory.edu.
Emory University · USNew York University · USUniversity of California, San Diego · USCenters for Disease Control and Prevention · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Detect: A novel device to assess how HIV affects neurocognitive decline and postural instability in older adults at risk for Alzheimer's DiseaseR01AG062387 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2019 to 2023
$3.9M
Study of zidovudine addition in HIV-associated neurocognitive disordersK23MH095679 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2013 to 2017
$899k
Viral immunocapture and isolation of virus from CSF lymphoid and myeloid cells to better understand HIV in the central nervous systemR21MH118092 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2018 to 2019
$437k
NIAID NIH HHS P30 AI050409NIA NIH HHS R01 AG062387NIMH NIH HHS K23 MH095679NIMH NIH HHS R21 MH118092
6 · The paper itself

Abstract

We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.

Indexed as

AdultAntiretroviral Therapy, Highly ActiveCognitionFemaleFollow-Up StudiesHIV InfectionsHumansImmunity, CellularMaleMiddle AgedRetrospective StudiesViral LoadAIDSCerebrospinal fluidCognitionFlow cytometryHIV

Identifiers

PMID32371201
PMCPMC8672395
OpenAlexW3017664355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.