SynthesisBrain, behavior, and immunity2020
The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.
Synthesis in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Sex-specific associations of depression with inflammatory markers: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Trial
- Trial
- Cortisol and C-reactive protein interact to predict depressive symptoms.Psychoneuroendocrinology · 2026Article
- Salivary vascular growth factor responses to prolonged and interrupted sitting in young, healthy adults.Physiological reports · 2026Article
- Modulation of autonomic responses to cognitive tasks under acute mental stress.Scientific reports · 2026Article
- Pre-analytical characterization of CNS-derived extracellular vesicles from human saliva: effect of room temperature and cellular origin.Frontiers in neuroscience · 2026Article
- Article
- Inflammation-related aberrations in beta and gamma oscillatory dynamics serving attention processing in typically developing youth.Brain communications · 2026Article
- Vegetable intake is associated with lower psychological stress via increased anti-inflammatory responses in pregnant women with chronic diseases.Brain, behavior, & immunity - health · 2025Article
- Multilevel and multimodal biobehavioral methods in the study of stress, trauma, and resilience: a systems approach.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Bridging acute and chronic stress effects on inflammation: protocol for a mixed-methods intensive longitudinal study.BMC psychology · 2025Article
- Acute Stress and Autoimmune Markers: Evaluating the Psychoneuroimmunology Axis in Firefighter Recruits.International journal of molecular sciences · 2025Article
- Evaluation of salivary nitric oxide levels and anxiety in multiple sclerosis patients, with and without Xerostomia: correlation with clinical variables.BMC oral health · 2025Observational
- Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers.BMC research notes · 2025Article
- Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes.Biology · 2025Review
- Toward diversification of acute stressors and precision stress research: A stage 2 Registered Report validating a reward-salient stress task in emerging adults.Journal of psychopathology and clinical science · 2025Article
- Seven robust and easy to obtain biomarkers to measure acute stress.Brain, behavior, & immunity - health · 2024Article
- The Interplay of Peer Victimization and Parasympathetic Nervous System Activity on Acute Inflammatory Stress Responses in Adolescence.Research on child and adolescent psychopathology · 2024Article
- Bibliometric Analysis and Visualization of Clinical Trials on Psychological Stress and Oral Health (1967-2024).Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSalivary biomarkers of inflammation are increasingly used in stress research. This systematic review and meta-analysis provides a quantitative summary of changes in salivary inflammatory markers in response to acute stress.
methodThe review included 1558 participants (42 unique samples, 33 studies) obtained through electronic databases (PubMed, PsycINFO, Embase), reference treeing, and articles identified by a 2015 review on a similar topic. To be eligible, articles had to be quantitative and assess change in at least one biomarker of salivary inflammation in response to acute stress in adults. The primary outcome was magnitude of change in inflammatory biomarkers (Cohen's d for repeated measures [d
resultsMeasures of salivary inflammation included: C-reactive protein (CRP), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, interferon (IFN)-α, IFN-γ, and tumor necrosis factor (TNF)-α. Cytokines IL-6 (k = 26, d
conclusionsThis meta-analysis revealed that certain salivary inflammatory cytokines increase in response to acute stress. Significant heterogeneity in results and moderator analyses suggest need for standardization of research protocols. Directions for future research are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.