ReviewRedox biology2020
Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases.
Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Long-term exposure to transportation noise and diabetes mellitus mortality: a national cohort study and updated meta-analysis.Environmental health : a global access science source · 2024Pooled it
- The association between the residential environment and arthritis among the elderly in China: evidence from cohort and cross-sectional studies.Journal of global health · 2026Article
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Short-term exposure to ambient air pollution and emergency ambulance dispatches for precipitous labor: a time-series study in Guangzhou, China.Scientific reports · 2026Article
- Protein Acylation Modifications in Sleep Disorders: Mechanisms and Therapeutic Potential.Journal of molecular neuroscience : MN · 2026Review
- Acute High-Intensity Noise Exposure Induces Cognitive Impairment and Arachidonic Acid Metabolism-Related Molecular Alterations in Rats: A Multi-Omics Study.Metabolites · 2026Article
- Effects of noise exposure and long working hours on oxidative stress levels and high-frequency hearing threshold damage in occupational populations.Frontiers in public health · 2026Article
- The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism.Military Medical Research · 2026Review
- Impact of Residential Noise Exposure on Neurological Health: A Systematic Scoping Review.Journal of urban health : bulletin of the New York Academy of Medicine · 2025Article
- Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12-17.Cardiovascular diabetology · 2025Article
- Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling.Die Naturwissenschaften · 2025Article
- Effects of air pollution and noise exposure on occupational hearing loss in oil workers: a prospective cohort study.BMC public health · 2025Article
- Correlation between nighttime sleep noise pollution and the risk of acute exacerbation of chronic obstructive pulmonary disease.BMC public health · 2025Article
- Combined exposure to night work and noise in relation to hyperglycemia among long-term night workers: a nationwide population-based prospective cohort study.Scandinavian journal of work, environment & health · 2025Article
- Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases.Pharmacological reports : PR · 2025Review
- Exposomic Determinants of Atherosclerosis: Recent Evidence.Current atherosclerosis reports · 2025Review
- Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage.Antioxidants (Basel, Switzerland) · 2025Article
- Projecting the economic burden of health impacts of aircraft noise: a case study of Baltimore Washington International Thurgood Marshall Airport.Journal of exposure science & environmental epidemiology · 2025Article
- The role of orexin and MCH neurons in the hypothalamus in sleep-wake regulation and learning-forgetting balance.Frontiers in neuroscience · 2025Review
- Systemic inflammatory response index mediates the association between stroke and hypertension: a cross-sectional study from NHANES 2001 to 2016.Frontiers in neurology · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental pollution and non-chemical stressors such as mental stress or traffic noise exposure are increasingly accepted as health risk factors with substantial contribution to chronic noncommunicable diseases (e.g. cardiovascular, metabolic and mental). Whereas the mechanisms of air pollution-mediated adverse health effects are well characterized, the mechanisms of traffic noise exposure are not completely understood, despite convincing clinical and epidemiological evidence for a significant contribution of environmental noise to overall mortality and disability. The initial mechanism of noise-induced cardiovascular, metabolic and mental disease is well defined by the "noise reaction model" and consists of neuronal activation involving the hypothalamic-pituitary-adrenal (HPA) axis as well as the sympathetic nervous system, followed by a classical stress response via cortisol and catecholamines. Stress pathways are initiated by noise-induced annoyance and sleep deprivation/fragmentation. This review highlights the down-stream pathophysiology of noise-induced mental stress, which is based on an induction of inflammation and oxidative stress. We highlight the sources of reactive oxygen species (ROS) involved and the known targets for noise-induced oxidative damage. Part of the review emphasizes noise-triggered uncoupling/dysregulation of endothelial and neuronal nitric oxide synthase (eNOS and nNOS) and its central role for vascular dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.