Evidence map›Paper›PMID 32370771›Full record

ArticleBMC complementary medicine and therapies2020

The role of Piper chaba Hunt. and its pure compound, piperine, on TRPV1 activation and adjuvant effect.

Sumalee Panthong, Yasuyuki Imai, Takeshi Matsuoka, Wakana Suzuki, Tatsuo Watanabe, Yuko Terada, Kohta Kurohane, Kota Sekiguchi, Erina Ogawa, Yukina Endo and 1 more

Open access · goldAbstract read
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In one paragraph

Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sumalee PanthongDepartment of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand.
Yasuyuki ImaiLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Takeshi MatsuokaLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Wakana SuzukiLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Tatsuo WatanabeLaboratory of Food Chemistry, School of Food and Nutritional Sciences|, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Yuko TeradaLaboratory of Food Chemistry, School of Food and Nutritional Sciences|, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Kohta KurohaneLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Kota SekiguchiLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Erina OgawaLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Yukina EndoLaboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, Shizuoka, 422-8526, Japan.
Arunporn ItharatDepartment of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand. iarunporn@yahoo.com.
University of Shizuoka · JPThammasat University · TH

Funding

Royal Golden Jubilee (RGJ) Ph.D. Programme PHD/0050/2554
6 · The paper itself

Abstract

backgroundPiper chaba Hunt. is used as an ingredient in Thai traditional preparation for arthritis. Its isolated compound is piperine which shows anti-inflammatory activity. Piperine produces a burning sensation because it activates TRPV1 receptor. The TRPV1 activation involved with the analgesic and adjuvant effect. P. chaba Hunt. has not been reported about TRPV1 activation and adjuvant effect. The aim of this study was to investigate the effect of P. chaba extract and piperine on TRPV1 receptor, which is considered as a target for analgesic and their adjuvant effects to support the development of an analgesic drug from herbal medicine.

methodsThe effect of P. chaba extract and piperine on HEK cells expressing TRPV1 channel was examined by calcium imaging assay. Adjuvant effects of P. chaba extract and piperine were investigated by a fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) model in mice.

resultsP. chaba extract induced calcium influx with EC

conclusionP. chaba extract and piperine activated TRPV1 channel and enhanced contact sensitization to FITC.

Indexed as

PiperAdjuvants, PharmaceuticAlkaloidsAnimalsBenzodioxolesHEK293 CellsHumansMiceMice, Inbred BALB CPiperidinesPlant ExtractsPolyunsaturated AlkamidesThailandTRPV Cation ChannelsAdjuvants, PharmaceuticAlkaloidsBenzodioxolesPiperidinespiperinePlant ExtractsPolyunsaturated AlkamidesTRPV1 receptorTRPV Cation ChannelsContact hypersensitivityPiper. chaba Hunt.PiperineTRPV1 activation

Identifiers

PMID32370771
PMCPMC7201532
OpenAlexW3022349981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.