ArticleJournal of the Royal Society, Interface2020
Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling.
Article in Journal of the Royal Society, Interface, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve Closure.Annals of biomedical engineering · 2026Article
- Simulation of Transcatheter Therapies for Atrioventricular Valve Regurgitation in an Open-Source Finite Element Simulation Framework.Annals of biomedical engineering · 2026Article
- Tricuspid Valve Is Transcriptionally Active During Prolonged Pressure Overload, Right-Sided Heart Failure, and Valve Regurgitation.Journal of the American Heart Association · 2026Article
- A nomogram risk prediction model for ischemic mitral regurgitation after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction.European journal of medical research · 2025Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- The Long-Term Survival of LVAD Patients-A TriNetX Database Analysis.Journal of clinical medicine · 2024Article
- Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves.Annals of biomedical engineering · 2024Article
- A Fast, Robust Method for Quantitative Assessment of Collagen Fibril Architecture from Transmission Electron Micrographs.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023Article
- A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State.Journal of biomechanical engineering · 2023Article
- Patient-Specific Quantitative In-Vivo Assessment of Human Mitral Valve Leaflet Strain Before and After MitraClip Repair.Cardiovascular engineering and technology · 2023Article
- Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures.The Journal of thoracic and cardiovascular surgery · 2023Article
- Quantitative in vivo assessment of human mitral valve coaptation area after undersized ring annuloplasty repair for ischemic mitral regurgitation.JTCVS techniques · 2022Article
- In vivo assessment of mitral valve leaflet remodelling following myocardial infarction.Scientific reports · 2022Article
- Alterations in Human Mitral Valve Mechanical Properties Secondary to Left Ventricular Remodeling: A Biaxial Mechanical Study.Frontiers in cardiovascular medicine · 2022Article
- Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains.Annals of biomedical engineering · 2021Article
- Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Commentary: The mitral valve and the left ventricle in functional mitral regurgitation: The puppet and the puppeteer.JTCVS open · 2021Article
- On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology.Cardiovascular engineering and technology · 2021Review
- The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Ischaemic mitral regurgitation (IMR), a frequent complication following myocardial infarction (MI), leads to higher mortality and poor clinical prognosis if untreated. Accumulating evidence suggests that mitral valve (MV) leaflets actively remodel post MI, and this remodelling increases both the severity of IMR and the occurrence of MV repair failures. However, the mechanisms of extracellular matrix maintenance and modulation by MV interstitial cells (MVICs) and their impact on MV leaflet tissue integrity and repair failure remain largely unknown. Herein, we sought to elucidate the multiscale behaviour of IMR-induced MV remodelling using an established ovine model. Leaflet tissue at eight weeks post MI exhibited significant permanent plastic radial deformation, eliminating mechanical anisotropy, accompanied by altered leaflet composition. Interestingly, no changes in effective collagen fibre modulus were observed, with MVICs slightly rounder, at eight weeks post MI. RNA sequencing indicated that YAP-induced genes were elevated at four weeks post MI, indicating elevated mechanotransduction. Genes related to extracellular matrix organization were downregulated at four weeks post MI when IMR occurred. Transcriptomic changes returned to baseline by eight weeks post MI. This multiscale study suggests that IMR induces plastic deformation of the MV with no functional damage to the collagen fibres, providing crucial information for computational simulations of the MV in IMR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.