ArticleEndocrine pathology1993
Immunohistochemical study of p53 protein in human and animal pituitary tumors.
Article in Endocrine pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- The PitNET Puzzle: From Zero to Linking Molecular Behavior with Neurosurgical Aspects.Medicina (Kaunas, Lithuania) · 2025Review
- Genomics and Epigenomics of Pituitary Tumors: What Do Pathologists Need to Know?Endocrine pathology · 2021Review
- Gene mutations in Cushing's disease.Biomedical reports · 2016Article
- Review
- Histological criteria for atypical pituitary adenomas - data from the German pituitary adenoma registry suggests modifications.Acta neuropathologica communications · 2015Article
- P53 gene mutations in pituitary carcinomas.Endocrine pathology · 2007Article
- Loss of heterozygosity of the MEN1 gene in a large series of TSH-secreting pituitary adenomas.Journal of endocrinological investigation · 2001Article
- Cyclins D1 and D3 and topoisomerase II alpha in inactive pituitary adenomas.Endocrine pathology · 2001Article
- hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias.Oncogene · 1999Article
- Adrenocorticotropin-Producing Pituitary Carcinoma with Expression of c-erbB-2 and High PCNA Index: A Comparative Study with Pituitary Adenomas and Normal Pituitary Tissues.Endocrine pathology · 1998Article
- Pituitary Carcinomas.Endocrine pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many human cancers, p53 gene mutations are frequently occurring genetic abnormalities, which may be detected by immunohistochemical staining for p53 protein. In the present study, p53 immunoreactivity was investigated in formalin-fixed, paraffin-embedded tissues from human and animal pituitary tumors, using the avidin-biotin-peroxidase complex technique. No p53 was detected in 3 nontumorous human adenohypophyses or in 40 human pituitary tumors including 5 GH cell adenomas, 10 PRL cell adenomas, 2 mixed GH cell-PRL cell adenomas, 2 acidophil stem cell adenomas, 8 ACTH cell adenomas, 1 TSH cell adenoma, 1 FSH/LH cell adenoma, 5 null cell adenomas, 5 oncocytomas, and 1 plurihormonal adenoma. Twenty nontumorous and hyperplastic pituitaries of hGRH transgenic mice and 8 tumors in these transgenic animals were immunonegative for p53. All pituitary tumors found in AVP/SV40 transgenic mice contained p53 immunoreactivity in the nuclei, while the nontumorous adenohypophysis of one such transgenic mouse was negative. It can be concluded that p53 mutations are apparently not involved in the pathogenesis of human pituitary adenomas or of the pituitary tumors which develop in hGRH transgenic mice. However, pituitary tumors in AVP/ SV40 transgenic mice are accompanied by p53 expression.
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Registered trials
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