ArticleEndocrine pathology1993
Squamous-cell nests in the pars tuberalis of the human pituitary: Immunocytochemical and in situ hybridization studies.
Article in Endocrine pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- [Ectopia of the pituitary].Der Pathologe · 2018Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-one autopsy-obtained human pituitaries were studied by histology, immunocytochemistry, and in situ hybridization to elucidate the characteristics of squamous-cell nests in the pars tuberaiis. Histologically, squamous-cell nests were composed of aggregates of squamous epithelial cells or squamous epithelial cells and adenohypophysial cells, which were immunoreactive mainly for FSH, LH, and the α-subunit (less frequently for ACTH). A gradual transition was seen from adenohypophysial cells to squamous cells at the periphery of several squamous-cell nests. Squamous-cell nests were immunoreactive for cytokeratin and EMA but were immunonegative for vimentin, demin, GFAP, S-100 protein, synaptophysin, chromogranin, and estrogen receptor. In situ hybridization revealed ER receptor mRNAs in both squamous-cell nests and adenohypophysial cells, but GH PRL, and POMC mRNAs could not be demonstrated in squamous-cell nests, and α-subunit mRNA was found only in 2 of 11 samples. Our results indicate that squamous-cell nests in the pars tuberalis derive by metaplasia from adenohypophysial cells rather than from remnants of the Rathke's pouch.Endocr Patho! 4:155-161,1993.
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