ArticleMaterials (Basel, Switzerland)2020
Fluorescence Spectroscopy Study of Protoporphyrin IX in Optical Tissue Simulating Liquid Phantoms.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- Quantification of dual-state 5-ALA-induced PpIX fluorescence: methodology and validation in tissue-mimicking phantoms.Physics in medicine and biology · 2026Article
- Imaging protoporphyrin IX photoproduct accumulation as a dosimetry reporter for monitoring photodynamic therapy of oral cancer.Journal of biomedical optics · 2025Article
- Development and characterization of a combined fluorescence and spatial frequency domain imaging system for real-time dosimetry of photodynamic therapy.Journal of biomedical optics · 2025Article
- Enabling point of care optical diagnostics and treatment of oral lesions in resource-limited settings: Preclinical development and evaluation of a low-cost theranostic intraoral device for image-guided photodynamic therapy.Biophotonics discovery · 2025Article
- Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer.EJNMMI research · 2024Article
- CRISPR/Cas9-MediatedInternational journal of molecular sciences · 2024Article
- A Low-Cost, Portable, Multi-Cancer Screening Device Based on a Ratio Fluorometry and Signal Correlation Technique.Biosensors · 2024Article
- Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy.Nature biomedical engineering · 2024Article
- Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.Journal of biomedical optics · 2023Article
- Label-free fluorescence microscopy: revisiting the opportunities with autofluorescent molecules and harmonic generations as biosensors and biomarkers for quantitative biology.Biophysical reviews · 2023Review
- A birefringent spectral demultiplexer enables fast hyper-spectral imaging of protoporphyrin IX during neurosurgery.Communications biology · 2023Article
- Optical Characterization of Biological Tissues Based on Fluorescence, Absorption, and Scattering Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Enhanced photoacoustic imaging in tissue-mimicking phantoms using polydopamine-shelled perfluorocarbon emulsion droplets.Ultrasonics sonochemistry · 2022Article
- Fluorescence Spectroscopy Study of Protoporphyrin IX in Optical Tissue Simulating Liquid Phantoms.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fluorescence spectroscopy has been extensively investigated for disease diagnosis. In this framework, optical tissue phantoms are widely used for validating the biomedical device system in a laboratory environment outside of clinical procedures. Moreover, it is fundamental to consider that there are several scattering components and chromophores inside biological tissues and the interplay between scattering and absorption may result in a distortion of the emitted fluorescent signal. In this work, the photophysical behaviour of a set of liquid, tissue-like phantoms containing different compositions was analysed: phosphate buffer saline (PBS) was used as the background medium, low fat milk as a scatterer, Indian ink as an absorber and protoporphyrin IX (PpIX) dissolved in dimethyl formamide (DMF) as a fluorophore. We examined the collected data in terms of the impact of surfactant Tween-20 on the background medium, scattering effects and combination of scattering and absorption within a luminescent body on PpIX. The results indicated that the intrinsic emission peaks are red shifted by the scattering particles or surfactant, whilst the scattering agent and the absorbent can alter the emission intensity substantially. We corroborated that phantoms containing higher surfactant content (>0.5% Tween 20) are essential to prepare stable aqueous phantoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.