Evidence map›Paper›PMID 32369920›Full record

ArticleBiomedicines2020

Preparation of Terpenoid-Invasomes with Selective Activity against

Bernhard P Kaltschmidt, Inga Ennen, Johannes F W Greiner, Robin Dietsch, Anant Patel, Barbara Kaltschmidt, Christian Kaltschmidt, Andreas Hütten

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Harnessing Ultrasonic Technologies to TreatMolecules (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Chemical Diversity ofPlants (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bernhard P KaltschmidtThin Films & Physics of Nanostructures, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Inga EnnenThin Films & Physics of Nanostructures, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Johannes F W GreinerDepartment of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.ORCID 0000-0002-0524-662X
Robin DietschFermentation and Formulation of Biologicals and Chemicals, Bielefeld University of Applied Sciences, Interaktion 1, 33619 Bielefeld, Germany.
Anant PatelFermentation and Formulation of Biologicals and Chemicals, Bielefeld University of Applied Sciences, Interaktion 1, 33619 Bielefeld, Germany.ORCID 0000-0003-1771-407X
Barbara KaltschmidtDepartment of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Christian KaltschmidtDepartment of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Andreas HüttenThin Films & Physics of Nanostructures, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.ORCID 0000-0002-1686-8387
Bielefeld University · DEHochschule Bielefeld · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terpenoids are natural plant-derived products that are applied to treat a broad range of human diseases, such as airway infections and inflammation. However, pharmaceutical applications of terpenoids against bacterial infection remain challenging due to their poor water solubility. Here, we produce invasomes encapsulating thymol, menthol, camphor and 1,8-cineol, characterize them via cryo transmission electron microscopy and assess their bactericidal properties. While control- and cineol-invasomes are similarly distributed between unilamellar and bilamellar vesicles, a shift towards unilamellar invasomes is observable after encapsulation of thymol, menthol or camphor. Thymol- and camphor-invasomes show a size reduction, whereas menthol-invasomes are enlarged and cineol-invasomes remain unchanged compared to control. While thymol-invasomes lead to the strongest growth inhibition of

Indexed as

bactericidalcamphorcineolE. coliinvasomesmentholS. aureusterpenoidsthymol

Identifiers

PMID32369920
PMCPMC7277086
OpenAlexW3023819262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.