ArticleMolecular cell2020
NAD
Open access · bronzeAbstract read
In one paragraph
Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- Meta-analysis of Diurnal Transcriptomics in Mouse Liver Reveals Low Repeatability of Rhythm Analyses.Journal of biological rhythms · 2023Pooled it
- Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Scientific reports · 2022Trial
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Article
- Bidirectional Mechanisms Linking Circadian Rhythm Disruption and Parkinson's Disease: Chronobiomarkers and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Multi-Omics Landscape of Circadian Clock Dysregulation Across the Chronic Liver Disease Spectrum.International journal of molecular sciences · 2026Review
- Article
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD.Brain : a journal of neurology · 2026Article
- Review
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- NADCommunications biology · 2026Article
- Biochemical mechanism of the mammalian circadian clock.FEBS letters · 2026Review
- Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Resveratrol and dexamethasone have cell-specific effects on the circadian clock but not on the rhythm of mitochondrial function in the fetal heart.Journal of physiology and biochemistry · 2026Article
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- The Role of Histone Modifications in Acute Lung Injury: Molecular Mechanisms and Potential of Traditional Chinese Medicine Treatment.Journal of inflammation research · 2026Review
- Dynamic Oxidative States: Interplay of Aging, Metabolic Stress, and Circadian Rhythms in Modulating Stroke Severity.Antioxidants (Basel, Switzerland) · 2025Review
- Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time.Life metabolism · 2025Review
- Circadian regulation of extracellular vesicle biogenesis, composition, and release.Npj biological timing and sleep · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byNAD2020
Authors and funding
13 authors at 4 institutions in 2 countries.
Daniel C LevineDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Heekyung HongDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Benjamin J WeidemannDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kathryn M RamseyDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Alison H AffinatiDepartment of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Mark S SchmidtDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Jonathan CedernaesDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Medical Sciences, Uppsala University, Uppsala SE-75124, Sweden.
Chiaki OmuraDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Rosemary BraunBiostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA; NSF-Simons Center for Quantitative Biology at Northwestern University, Evanston, IL 60208, USA.
Choogon LeeDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.
Charles BrennerDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Clara Bien PeekDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: j-bass@northwestern.edu.
Northwestern University · USUniversity of Iowa · USFlorida State University · USMichigan Medicine · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MSLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MTRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2MMedical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1MIntegration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9MThe SIRT1-Gpd1L-NAD+ interactome in regulation of the Neuronal Sodium Channel: Implications for Cognitive Impairment of Alzheimerâs DementiaR01HL147545 · NHLBI · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M, IRANI, KAIKOBAD J. · 2019 to 2022
$2.9MInterplay of Dietary Lipid and Circadian Dysregulation in Metabolic SyndromeR01DK100814 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2014 to 2018
$2.3MBioenergetic Mechanisms Underlying Circadian Dietary InterventionR01AG065988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2019 to 2023
$2.0MThe Circadian System as a Neuronal Regulator of Feeding Time and Body Weight SetpointR01DK113011 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2018 to 2021
$1.7MNational Science Foundation 1764421NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL147545NHLBI NIH HHS T32 HL007909NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG065988NIDDK NIH HHS F30 DK116481NIDDK NIH HHS K01 DK105137NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK100814NIDDK NIH HHS R01 DK113011NIDDK NIH HHS R03 DK116012NIGMS NIH HHS P41 GM108569NIGMS NIH HHS T32 GM008152NIGMS NIH HHS T32 GM144295NINDS NIH HHS R21 NS099813
Abstract
Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD
Indexed as
Age FactorsAgingAnimalsARNTL Transcription FactorsCircadian ClocksCircadian RhythmCLOCK ProteinsCytokinesFemaleHEK293 CellsHumansMaleMiceMice, Inbred C57BLNADPeriod Circadian ProteinsARNTL Transcription FactorsCLOCK ProteinsCytokinesNADPER2 protein, humanPer2 protein, mousePeriod Circadian ProteinsSirtuin 1Sirtuinsagingcircadianclockheat shock factor 1liverNAD(+)nicotinamide mononucleotidenicotinamide ribosideSIRT1transcriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.