SynthesisPloS one2020
Accelerated weight gain, prematurity, and the risk of childhood obesity: A meta-analysis and systematic review.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Effects of Maternal Exercise During Pregnancy on Perinatal Growth and Childhood Obesity Outcomes: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Pooled it
- Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.Pediatric research · 2024Trial
- Breastfeeding type is associated with urinary metabolic changes in early life: influence of sex and early weight gain in healthy term infants.Molecular and cellular pediatrics · 2026Article
- Impact of Prematurity on Nutrient Signaling and Protein Synthesis in Skeletal Muscle.Annual review of nutrition · 2026Review
- Body composition at 2 years of age in moderate and late preterm infants.Journal of pediatric gastroenterology and nutrition · 2026Article
- Lifestyle behaviours in children born extremely preterm at 2 years: a comparison to a Dutch reference population.European journal of pediatrics · 2026Article
- Neighborhood socioeconomic disadvantage and early overweight of very preterm-born children: a cohort study in France.Pediatric research · 2026Article
- Maternal multimorbidity, lifestyle behaviours during pregnancy, and early-childhood growth trajectories: a register-based cohort study.The Lancet regional health. Western Pacific · 2026Article
- Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge.Molecular nutrition & food research · 2026Article
- Odds of Developing Overweight or Obesity Increase with Height Decile in Tall Healthy Weight Kindergarteners: Longitudinal Results from the West Virginia Coronary Artery Risk Detection In Appalachian Communities (WV CARDIAC) Project.Journal of pediatrics. Clinical practice · 2026Article
- A retrospective cohort study evaluating the growth and clinical outcomes of preterm and term infants with cystic fibrosis during the first 11 years of life.JPGN reports · 2026Article
- Association between size at birth, rapid weight gain in infancy, and overweight status among Palestinian refugees under 5 years old: a retrospective cohort study.The American journal of clinical nutrition · 2026Article
- Hydrocortisone administration in preterm infants is not associated with adverse cardiovascular outcomes in childhood.Pediatric research · 2026Article
- Maternal hypertension and telomere length are associated with weight for age Z score change from birth to 6 months of age in a predominantly Latinx cohort.BMC pregnancy and childbirth · 2025Article
- Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus).International journal of obesity (2005) · 2025Article
- Early Infancy Weight Gain Patterns Are Associated with Child Body Mass Index in Singletons but Not Twins.The Journal of pediatrics · 2025Article
- Mediating Effect of Infant Rapid Weight Gain on the Association Between Exclusive Breastfeeding and the Risk of Obesity Later in Life.Pediatric obesity · 2025Observational
- Early Life Determinants of Overweight and Obesity in a Sample of Mexico City Preschoolers.Nutrients · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this systematic review and meta-analysis of the literature was to analyze and evaluate the impact of prematurity and accelerated weight gain on the risk of childhood and adolescent obesity. CINAHL, Embase, PubMed, and Web of Science databases were searched until December 2019 which yielded 19 studies with a total of 169,439 children enrolled were systematically reviewed. The results revealed that preterm infants had a greater likelihood of childhood obesity (defined as BMI ≥95th percentile for age-sex), than term infants (OR = 1.19, 95% CI [1.13, 1.26]). However, no difference of childhood obesity was found between "small for gestational age"(SGA) and "appropriate for gestational age"(AGA) among preterms. Accelerated weight gain (defined as weight gain velocity during first two years after birth) significantly increased the likelihood of subsequent childhood obesity among preterms (aOR = 1.87, 95% CI [1.57, 2.231]). In conclusion, accelerated weight gain at infancy among preterm children may be a critical contributor to obesity in later life. Establishing optimal growth trajectories and timely referral to health care providers may be of clinical importance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.