Evidence map›Paper›PMID 32369487›Full record

ArticlePloS one2020

Differential asthma odds following respiratory infection in children from three minority populations.

Eric M Wohlford, Luisa N Borrell, Jennifer R Elhawary, Brian Plotkin, Sam S Oh, Thomas J Nuckton, Celeste Eng, Sandra Salazar, Michael A LeNoir, Kelley Meade and 9 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. The PRIMERO birth cohort: Design and baseline characteristics.The journal of allergy and clinical immunology. Global · 2025
    Article
  4. Article
  5. Latino-white disparities in ICD-coded asthma diagnosis among US children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Everyone must be able to breathe: a plan to support diversity and inclusion in respiratory physiology.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Eric M WohlfordDepartment of Medicine, University of California, San Francisco, CA, United States of America.ORCID 0000-0002-0116-6112
Luisa N BorrellDepartment of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, United States of America.ORCID 0000-0002-0560-4853
Jennifer R ElhawaryDepartment of Medicine, University of California, San Francisco, CA, United States of America.ORCID 0000-0003-3326-1680
Brian PlotkinDepartment of Medicine, University of California, San Francisco, CA, United States of America.
Sam S OhDepartment of Medicine, University of California, San Francisco, CA, United States of America.ORCID 0000-0002-2815-6037
Thomas J NucktonDepartment of Medicine, University of California, San Francisco, CA, United States of America.ORCID 0000-0001-7324-2332
Celeste EngDepartment of Medicine, University of California, San Francisco, CA, United States of America.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, CA, United States of America.
Michael A LeNoirBay Area Pediatrics, Oakland, CA, United States of America.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, CA, United States of America.ORCID 0000-0001-5225-4713
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, United States of America.ORCID 0000-0002-2792-7012
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, United States of America.ORCID 0000-0003-0521-6460
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, CA, United States of America.ORCID 0000-0002-9066-7444
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico, United States of America.
Rajesh KumarThe Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States of America.
Shannon ThyneDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States of America.
Max A SeiboldNational Jewish Health, Denver, CO, United States of America.ORCID 0000-0002-8685-4263
José R Rodríguez-SantanaCentro de Neumologia Pediátrica, Caguas, Puerto Rico, United States of America.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, CA, United States of America.ORCID 0000-0001-7475-2035
University of California, San Francisco · USBaylor College of Medicine · USCentro de Neumologia Pediatrica · PRCity University of New York · USJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLurie Children's Hospital · USNational Jewish Health · USUniversity of California, Los Angeles · USVA Caribbean Healthcare System · PR

Funding

Natural History of Viral Induced Airway Dysfunction and Asthma in Minority ChildrenU01HL138626 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RODRIGUEZ-SANTANA, JOSE, SEIBOLD, MAX A · 2018 to 2022
$10.0M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Genetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1M
Integrative Analyses to Uncover Biological Mechanisms Mediating Gene Associations with Asthma Drug Response Among Minority ChildrenR01HL141992 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BURCHARD, ESTEBAN GONZALEZ, HIMES, BLANCA E · 2018 to 2019
$855k
Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509k
NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141992NHLBI NIH HHS U01 HL138626NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS T32 GM007546NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

rationaleSevere early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in particular have a strikingly high asthma burden. However, prior studies of the potential associations between early-life respiratory illnesses and asthma in Puerto Rican and other minority populations have been limited.

objectivesWe sought to determine whether early-life respiratory illness was associated with asthma in Puerto Rican, Mexican American, and African American children.

methodsUsing a logistic regression analysis, we examined the association between early-life respiratory illnesses (report of upper respiratory infection (URI), pneumonia, bronchitis, and bronchiolitis/RSV) within the first two years of life and physician-diagnosed asthma after the age of two in a large cohort of Puerto Rican, Mexican American, and African American children. MEASUREMENTS AND MAIN

resultsWhile early-life respiratory illnesses were associated with greater asthma odds in Puerto Ricans, Mexican Americans, and African Americans, these associations were stronger among Puerto Rican children. Specifically, in Puerto Ricans, the odds was 6.15 (95% CI: 4.21-9.05) if the child reported at least one of the following respiratory illness: URI, pneumonia, bronchitis or bronchiolitis. The odds were also higher in Puerto Ricans when considering these conditions separately.

conclusionsWe observed population-specific associations between early-life respiratory illnesses and asthma, which were especially significant and stronger in Puerto Ricans. Taken together with the known high burden of RSV in Puerto Rico, our results may help explain the high burden of asthma in Puerto Ricans.

Indexed as

AdolescentAsthmaBlack or African AmericanChildChild, PreschoolFemaleHispanic or LatinoHumansInfantLogistic ModelsMaleMexican AmericansRespiratory Tract InfectionsUnited StatesYoung Adult

Identifiers

PMID32369487
PMCPMC7199930
OpenAlexW3021453154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.