ArticleAnnals of clinical and translational neurology2020
Automated cot-side tracking of functional brain age in preterm infants.
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 57 citations in OpenAlex.
- Frontal lead in preterm functional brain maturation.Developmental cognitive neuroscience · 2026Article
- Neonatal brain-age models in full- and preterm infants.Developmental cognitive neuroscience · 2026Article
- Early Maturation of Heart Rate Variability in Very Preterm Infants Depends on Neonatal Factors and Is Associated With Neurodevelopmental Risk.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Neonatal brain-age models in full- and preterm infants.bioRxiv : the preprint server for biology · 2026Article
- Toward automated neonatal EEG analysis: multi-center validation of a reliable deep learning pipeline.Frontiers in neuroscience · 2026Article
- Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates.Frontiers in pediatrics · 2026Article
- Decoding brain age predictions from sleep electroencephalography across infancy to adolescence.Scientific reports · 2025Article
- Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- EEG Maturational Age Estimation: A Comparison of Visual and Automated Interpretation of the EEG in Preterm Infants.Journal of clinical medicine · 2025Article
- Emergence of a synergistic scaffold in the brains of human infants.Communications biology · 2025Article
- Quantitative EEG features during the first day correlate to clinical outcome in perinatal asphyxia.Pediatric research · 2025Article
- Depression of cortical neuronal activity after a low-dose fentanyl in preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Optimal channel and feature selection for automatic prediction of functional brain age of preterm infant based on EEG.Frontiers in neuroscience · 2025Article
- Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Knowledge mapping of neonatal electroencephalogram: A bibliometric analysis (2004-2022).Brain and behavior · 2024Article
- Microstate Analysis Reflects Maturation of the Preterm Brain.Brain topography · 2024Article
- A growth chart of brain function from infancy to adolescence based on EEG.EBioMedicine · 2024Article
- Sensory event-related potential morphology predicts age in premature infants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Early EEG-burst sharpness and 2-year disability in extremely preterm infants.Pediatric research · 2024Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA major challenge in the care of preterm infants is the early identification of compromised neurological development. While several measures are routinely used to track anatomical growth, there is a striking lack of reliable and objective tools for tracking maturation of early brain function; a cornerstone of lifelong neurological health. We present a cot-side method for measuring the functional maturity of the newborn brain based on routinely available neurological monitoring with electroencephalography (EEG).
methodsWe used a dataset of 177 EEG recordings from 65 preterm infants to train a multivariable prediction of functional brain age (FBA) from EEG. The FBA was validated on an independent set of 99 EEG recordings from 42 preterm infants. The difference between FBA and postmenstrual age (PMA) was evaluated as a predictor for neurodevelopmental outcome.
resultsThe FBA correlated strongly with the PMA of an infant, with a median prediction error of less than 1 week. Moreover, individual babies follow well-defined individual trajectories. The accuracy of the FBA applied to the validation set was statistically equivalent to the training set accuracy. In a subgroup of infants with repeated EEG recordings, a persistently negative predicted age difference was associated with poor neurodevelopmental outcome.
interpretationThe FBA enables the tracking of functional neurodevelopment in preterm infants. This establishes proof of principle for growth charts for brain function, a new tool to assist clinical management and identify infants who will benefit most from early intervention.
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