Evidence map›Paper›PMID 32368735›Full record

ArticleFood frontiers2020

Black raspberries suppress pancreatic cancer through modulation of NKp46

Pan Pan, Zheng Zhu, Kiyoko Oshima, Mohammed Aldakkak, Susan Tsai, Yi-Wen Huang, Wenjuan Dong, Jianying Zhang, Chien-Wei Lin, Youwei Wang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Food frontiers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Ginsenoside Rb1 From the Functional FoodFood science & nutrition · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Pan PanDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin.
Zheng ZhuDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.
Kiyoko OshimaDepartment of Pathology, Johns Hopkins University.
Mohammed AldakkakDepartment of Surgery, Medical College of Wisconsin.
Susan TsaiDepartment of Surgery, Medical College of Wisconsin.
Yi-Wen HuangDepartment of Obstetrics and Gynecology, Medical College of Wisconsin.
Wenjuan DongDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.
Jianying ZhangDivision of Biostatistics, Department of Science of Informatics, City of Hope National Medical Center and Beckman Research Institute.
Chien-Wei LinDivision of Biostatistics, Medical College of Wisconsin.
Youwei WangThe James Cancer Hospital, The Ohio State University.
Martha YearsleyDepartment of Pathology, The Ohio State University.
Jianhua YuDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.
Li-Shu WangDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin.
Medical College of Wisconsin · USCity Of Hope National Medical Center · USJohns Hopkins University · USThe Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
IL-15--CHARACTERIZATION THROUGH EXPERIMENTAL IMMUNOLOGYR01CA068458 · NCI · ROSWELL PARK CANCER INSTITUTE · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 1996 to 2019
$4.5M
Characterizing and Targeting the Novel IL-15- AKT-XBP1s Pathway in NK CellsR01CA247550 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YU, JIANHUA · 2020 to 2024
$2.2M
Elucidate and Modulate Cell Signaling in NK Cells for Glioma TreatmentR01AI129582 · NIAID · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2017 to 2021
$2.1M
Overcoming Barriers of Virotherapy by Next-Generation oHSV Expressing E-CadherinR01NS106170 · NINDS · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2018 to 2023
$1.9M
Enhancing NK Cell Activity by Dietary Diphyllin Lignans for Cancer PreventionR01CA185301 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 2015 to 2019
$1.8M
Mechanisms of tumor suppressor gene reactivation in colon cancer by berriesR01CA148818 · NCI · OHIO STATE UNIVERSITY · PI WANG, LI-SHU · 2010 to 2014
$1.5M
scFvPD1-FLT3 CAR T Cells for the Treatment of Relapsed Acute Myeloid LeukemiaR21CA223400 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YU, JIANHUA · 2019 to 2020
$414k
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA068458NCI NIH HHS R01 CA148818NCI NIH HHS R01 CA185301NCI NIH HHS R01 CA247550NCI NIH HHS R21 CA223400NIAID NIH HHS R01 AI129582NINDS NIH HHS R01 NS106170
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a low survival rate (9%). Epidemiologic studies show that healthy dietary patterns enriched of fruits and vegetables lower the risk of PDAC. We previously showed that supplementing black raspberries (BRBs) to patients with colorectal cancer increased tumor-infiltrating NK cells and their cytotoxicity. We aimed to determine whether BRBs combat PDAC by modulating cancer immunity. NOD.SCID mice lacking T and B cells were injected with human Panc-1-Luc cells orthotopically, and immunocompetent

Indexed as

black raspberriesbutyratecancer immunityKrasLSL.G12D/+-Trp53LSL.R172H/+-Pdx-1-Creorthotopic xenograftPancreatic ductal adenocarcinomaPDAC patients

Identifiers

PMID32368735
PMCPMC7197210
OpenAlexW3013880304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.