Evidence map›Paper›PMID 32368720›Full record

ArticleNature catalysis2020

Copper-catalysed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering.

Huayou Hu, Si-Jie Chen, Mukunda Mandal, Saied Md Pratik, Joshua A Buss, Shane W Krska, Christopher J Cramer, Shannon S Stahl

Abstract read
In one paragraph

Article in Nature catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 192 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Enantioconvergent Chan-Evans-Lam C(spJournal of the American Chemical Society · 2026
    Article
  5. Article
  6. Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Copper-catalyzed C(spNature communications · 2025
    Article
  14. A General Strategy for C(spAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Direct Benzylic C-H Etherification Enabled by Base-Promoted Halogen Transfer.Angewandte Chemie (International ed. in English) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Huayou HuDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.
Si-Jie ChenDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.
Mukunda MandalDepartment of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Saied Md PratikDepartment of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Joshua A BussDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.
Shane W KrskaHigh-Throughput Experimentation and Lead Discovery Capabilities, Merck & Co., Inc., Kenilworth, NJ, USA.
Christopher J CramerDepartment of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Shannon S StahlDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA.
University of Wisconsin–Madison · USUniversity of Minnesota · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Radical Relay Methods for Selective C-H OxidationR01GM126832 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI STAHL, SHANNON S · 2018 to 2019
$595k
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
The Development of Enantioselective Nickel Catalysts for Late Stage Functionalization of Benzylic C–H BondsF32GM129909 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUSS, JOSHUA A · 2018 to 2019
$109k
NIGMS NIH HHS F32 GM129909NIGMS NIH HHS R01 GM126832NIH HHS S10 OD020022
6 · The paper itself

Abstract

Cross-coupling reactions enable rapid, convergent synthesis of diverse molecules and provide the foundation for modern chemical synthesis. The most widely used methods employ sp

Identifiers

PMID32368720
PMCPMC7197765
OpenAlexW3008949264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.