ArticleTranslational medicine of aging2018
Translational Geroscience: From invertebrate models to companion animal and human interventions.
Article in Translational medicine of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Transcriptomic investigation of agonistic behaviors of boxer shrimps (Stenopus species): insights into the potential neural signaling roles of dopamine and acetylcholine.BMC genomics · 2026Article
- Systematic Review: Exploring Inter-Species Variability in Diabetes Mellitus for Translational Medicine.Life (Basel, Switzerland) · 2025Review
- A wearable-based aging clock associates with disease and behavior.Nature communications · 2025Observational
- In Silico Assessment of Potential Geroprotectors: From Separate Endpoints to Complex Pharmacotherapeutic Effects.International journal of molecular sciences · 2025Article
- After all, how valuable is the dog model for examining human socio-cognitive abilities?Biologia futura · 2025Review
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- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
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- New Directions in Research on Aging.Stem cell reviews and reports · 2022Article
- Antiaging diets: Separating fact from fiction.Science (New York, N.Y.) · 2021Review
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- Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission.GeroScience · 2021Review
- Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs.Aging · 2021Article
- Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration.Oxidative medicine and cellular longevity · 2021Review
- Review
- The importance of diversity and outreach in geroscience research: Insights from the Annual Biomedical Research Conference for Minority Students.GeroScience · 2020Article
- DDS promotes longevity through a microbiome-mediated starvation signal.Translational medicine of aging · 2019Article
- Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast.Translational medicine of aging · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan. In this review, we describe a research pipeline for the identification and validation of lifespan extending interventions. Beginning in invertebrate model systems, interventions are discovered and then characterized using other invertebrate model systems (evolutionary translation), models of genetic diversity, and disease models. Vertebrate model systems, particularly mice, can then be utilized to validate interventions in mammalian systems. Collaborative, multi-site efforts, like the Interventions Testing Program (ITP), provide a key resource to assess intervention robustness in genetically diverse mice. Mouse disease models provide a tool to understand the broader utility of longevity interventions. Beyond mouse models, we advocate for studies in companion pets. The Dog Aging Project is an exciting example of translating research in dogs, both to develop a model system and to extend their healthy lifespan as a goal in itself. Finally, we discuss proposed and ongoing intervention studies in humans, unmet needs for validating interventions in humans, and speculate on how differences in survival among human populations may influence intervention efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.