Evidence map›Paper›PMID 32368695›Full record

ArticleJACC. Basic to translational science2020

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular

Mia Ståhle, Johanna M U Silvola, Sanna Hellberg, Margreet de Vries, Paul H A Quax, Jeffrey Kroon, Petteri Rinne, Alwin de Jong, Heidi Liljenbäck, Nina Savisto and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Targeting Phosphorylcholine in Established Atherosclerosis?JACC. Basic to translational science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Mia StåhleTurku PET Centre, University of Turku, Turku, Finland.
Johanna M U SilvolaTurku PET Centre, University of Turku, Turku, Finland.
Sanna HellbergTurku PET Centre, University of Turku, Turku, Finland.
Margreet de VriesEinthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Paul H A QuaxEinthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Jeffrey KroonDepartment of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Petteri RinneResearch Center for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Alwin de JongEinthoven Laboratory for Experimental Vascular Medicine, Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Heidi LiljenbäckTurku PET Centre, University of Turku, Turku, Finland.
Nina SavistoTurku PET Centre, University of Turku, Turku, Finland.
Anna Wickmani3tex AB, Gothenburg, Sweden.
Erik S G StroesDepartment of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Seppo Ylä-HerttualaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Pekka SaukkoDepartment of Pathology and Forensic Medicine, University of Turku, Turku, Finland.
Tommy AbrahamssonAthera Biotechnologies AB, Stockholm, Sweden.
Knut PetterssonAthera Biotechnologies AB, Stockholm, Sweden.
Juhani KnuutiTurku PET Centre, University of Turku, Turku, Finland.
Anne RoivainenTurku PET Centre, University of Turku, Turku, Finland.
Antti SarasteTurku PET Centre, University of Turku, Turku, Finland.
University of Turku · FILeiden University Medical Center · NLTurku PET Centre · FIAmsterdam University Medical Centers · NLAthera (Sweden) · SEUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of

Indexed as

18F-FDG, 18F-fluorodeoxyglucose18F-fluorodeoxyglucose positron emission tomographyANOVA, analysis of varianceApoB, apolipoprotein-BatherosclerosisCFR, coronary flow reservecoronary flow reserveHAEC, human aortic endothelial cellICAM, intracellular adhesion moleculeIg, immunoglobulinIL, interleukininflammationLDLR, low-density lipoprotein receptorLp(a), lipoprotein(a)NO, nitric oxideOxLDL, oxidized low-density lipoprotein cholesterolOxPLs, oxidized phospholipidsPC-mAb, human PC antibodyPC, phosphorylcholinephosphorylcholineVCAM, vascular cell adhesion molecule

Identifiers

PMID32368695
PMCPMC7188869
OpenAlexW3013881311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.