Evidence map›Paper›PMID 32368694›Full record

ArticleJACC. Basic to translational science2020

In Vivo Imaging of Venous Thrombus and Pulmonary Embolism Using Novel Murine Venous Thromboembolism Model.

Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Yasuhiro Irino, Seimi Satomi-Kobayashi, Masakazu Shinohara, Ryuji Toh, Farouc A Jaffer, Tatsuro Ishida, Ken-Ichi Hirata

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Piperine alleviates retinal ischemic injury by mediating the APE1 signaling.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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  3. The role of chondroitin sulfate in venous thrombosis, organization, and resolution.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  4. Humanized murine models of platelet function.Current opinion in hematology · 2025
    Review
  5. Article
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  9. Intravital Microscopy in Atherosclerosis Research.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. Article
  11. Visualizing thrombosis to improve thrombus resolution.Research and practice in thrombosis and haemostasis · 2021
    Article
  12. Shining a Light on Venous Thromboembolism.JACC. Basic to translational science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mitsumasa OkanoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tetsuya HaraDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Makoto NishimoriDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasuhiro IrinoDivision of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Seimi Satomi-KobayashiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Masakazu ShinoharaDivision of Epidemiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Ryuji TohDivision of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Farouc A JafferCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.
Tatsuro IshidaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Ken-Ichi HirataDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobe University · JPMassachusetts General Hospital · US

Funding

Novel PET/CT and Treatment Strategies to reduce PTS following DVTR01HL137913 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN, TAWAKOL, AHMED A · 2017 to 2020
$3.3M
NHLBI NIH HHS R01 HL137913
6 · The paper itself

Abstract

This work established a new murine venous thromboembolism (VTE) model. This model has multiple novel features representing clinical VTE that include the following: 1) deep venous thrombosis (DVT) was formed and extended in the long axis of femoral/saphenous vein; 2) thrombus was formed in a venous valve pocket; 3) deligation of suture-induced spontaneous pulmonary emboli of fibrin-rich DVT; and 4) cardiac motion-free femoral/saphenous vein allowed high-resolution intravital microscopic imaging of fibrin-rich DVT. This new model requires only commercially available epifluorescence microscopy. Therefore, this model has significant potential for better understanding of VTE pathophysiology.

Indexed as

2-photon microscopydeep vein thrombosisDVT, deep venous thrombosisFITC, fluorescein isothiocyanateimagingIQR, interquartile rangeIVC, inferior vena cavaPE, pulmonary embolismpulmonary embolismROS, reactive oxygen speciesvenous thromboembolismVTE, venous thromboembolism

Identifiers

PMID32368694
PMCPMC7188875
OpenAlexW3012225876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.