ArticleJACC. Basic to translational science2020
In Situ Immune Profiling of Heart Transplant Biopsies Improves Diagnostic Accuracy and Rejection Risk Stratification.
Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 23 citations in OpenAlex.
- Multiplex immunofluorescence in the identification of immune cell compositions in rejection, bronchus-associated lymphoid tissue, and infection in lung allograft tissue.Virchows Archiv : an international journal of pathology · 2026Article
- Prognostic value of early cardiac magnetic resonance first-pass perfusion assessment of microcirculatory dysfunction for acute rejection after heart transplantation.Cardiovascular diagnosis and therapy · 2026Article
- Cardiac sarcoidosis: new insights beyond the granuloma using spatial proteomics.European heart journal · 2026Article
- Expression of PD-1/PD-L1 pathway molecules in human cardiac allograft according to acute cellular rejection status: insights from a Korean Heart Transplant Cohort.Journal of pathology and translational medicine · 2026Article
- Association of Longitudinal High-Sensitivity Cardiac Troponin T With Clinical Outcomes in Adult Heart-Transplant Recipients.Journal of the American Heart Association · 2026Article
- From the Bench to the Bedside and Back: Contemporary Applications of Basic Science to Innovations in Heart Transplantation.The Canadian journal of cardiology · 2026Review
- A stage-based framework to interpret regulatory T cell biology after heart transplantation.Frontiers in cardiovascular medicine · 2026Review
- Review
- Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant.Communications medicine · 2025Article
- Computational Pathology Assessments of Cardiac Stromal Remodeling: Clinical Correlates and Prognostic Implications in Heart Transplantation.Research square · 2024Article
- Failing to Make the Grade: Conventional Cardiac Allograft Rejection Grading Criteria Are Inadequate for Predicting Rejection Severity.Circulation. Heart failure · 2024Article
- European Society for Organ Transplantation (ESOT) Consensus Statement on the Use of Non-invasive Biomarkers for Cardiothoracic Transplant Rejection Surveillance.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- The evolving use of biomarkers in heart transplantation: Consensus of an expert panel.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Review
- Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy.Circulation · 2022Article
- PD-1 expression in transbronchial biopsies of lung transplant recipients is a possible early predictor of rejection.Frontiers in immunology · 2022Observational
- Nuclear deformation guides chromatin reorganization in cardiac development and disease.Nature biomedical engineering · 2021Article
- Insight into Noninvasive Radiological Modalities to Detect Heart Transplant Rejection.The Indian journal of radiology & imaging · 2021Review
- Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8Circulation. Heart failure · 2021Article
- Is it Time for Trials on Preventing Immune-Mediated Myocardial Damage?JACC. Basic to translational science · 2021Article
- Deep Neural Network-Aided Histopathological Analysis of Myocardial Injury.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Recognizing that guideline-directed histologic grading of endomyocardial biopsy tissue samples for rejection surveillance has limited diagnostic accuracy, quantitative, in situ characterization was performed of several important immune cell types in a retrospective cohort of clinical endomyocardial tissue samples. Differences between cases were identified and were grouped by histologic grade versus clinical rejection trajectory, with significantly increased programmed death ligand 1+, forkhead box P3+, and cluster of differentiation 68+ cells suppressed in clinically evident rejections, especially cases with marked clinical-histologic discordance. Programmed death ligand 1+, forkhead box P3+, and cluster of differentiation 68+ cell proportions are also significantly higher in "never-rejection" when compared with "future-rejection." These findings suggest that in situ immune modulators regulate the severity of cardiac allograft rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.