Evidence map›Paper›PMID 32368615›Full record

ArticleMolecular therapy oncolytics2020

Ectopic Expression of miR-532-3p Suppresses Bone Metastasis of Prostate Cancer Cells via Inactivating NF-κB Signaling.

Qingde Wa, Changye Zou, Zhuoyuan Lin, Sheng Huang, Xinsheng Peng, Chunxiao Yang, Dong Ren, Dongchu Xu, Yuanqing Guo, Zhuangwen Liao and 4 more

Abstract read
In one paragraph

Article in Molecular therapy oncolytics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Versatile function of NF-ĸB in inflammation and cancer.Experimental hematology & oncology · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Life science alliance · 2023
    Article
  14. Article
  15. Muscle and Bone Defects in Metastatic Disease.Current osteoporosis reports · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qingde WaDepartment of Orthopedic Surgery, The Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
Changye ZouDepartment of Orthopedic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Zhuoyuan LinDepartment of Urology Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Sheng HuangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xinsheng PengDepartment of Orthopedic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Chunxiao YangDepartment of Clinical Cytogenetics, Suzhou Precision Medicine Scientific Ltd., Suzhou 215006, China.
Dong RenDepartment of Orthopedic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Dongchu XuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Yuanqing GuoDepartment of Orthopedic Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519099, China.
Zhuangwen LiaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Bin WangDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Hailan HuDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Shuai HuangDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Peiheng HeDepartment of Orthopedic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miR-532-3p is a widely documented microRNA (miRNA) involved in multifaceted processes of cancer tumorigenesis and metastasis. However, the clinical significance and biological functions of miR-532-3p in bone metastasis of prostate cancer (PCa) remain largely unknown. Herein, we report that miR-532-3p was downregulated in PCa tissues with bone metastasis, and downexpression of miR-532-3p was significantly associated with Gleason grade and serum prostate-specific antigen (PSA) levels and predicted poor bone metastasis-free survival in PCa patients. Upregulating miR-532-3p inhibited invasion and migration abilities of PCa cells

Indexed as

bone metastasismiR-532-3pNF-κB signalingprostate cancer

Identifiers

PMID32368615
PMCPMC7191128

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.