ReviewIntegrated blood pressure control2020
Isolated Nocturnal Hypertension: What Do We Know and What Can We Do?
Review in Integrated blood pressure control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Timing of antihypertensive medication (bedtimeFrontiers in pharmacology · 2026Pooled it
- Sleep quality, isolated nocturnal hypertension, and cardiovascular risk: clarifying a complex relationship.Journal of human hypertension · 2026Article
- Does a non-dipping heart rate profile predict adverse maternal-fetal outcomes? evidence from 24-h ambulatory monitoring in the second half of high-risk pregnancies.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Bridging the Gap in Racial/Ethnic Disparities: Perspectives from the 2025 American Heart Association/American College of Cardiology High Blood Pressure Guideline.Current hypertension reports · 2026Review
- The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs.Health science reports · 2026Review
- Associations of triglyceride-glucose-body mass Index and C-reactive protein with isolated nocturnal hypertension: evidence from a retrospective observational study.Frontiers in cardiovascular medicine · 2026Article
- Study on the ambulatory blood pressure phenotype and its correlation with hemoglobin concentration in untreated hypertensive individuals permanently living in plateau areas.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Article
- Controversies in hypertension therapy: bedtime dosing or daytime dosing?Journal of hypertension · 2025Review
- Article
- Effect of Cuff Inflation on Blood Pressure, Arousals, Sleep Efficiency, and Desaturations: Sub-Analysis of the VAST Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Prevalence and Characteristics of Isolated Nocturnal Hypertension and Masked Nocturnal Hypertension in a Tertiary Hospital in the City of Buenos Aires.Diagnostics (Basel, Switzerland) · 2023Article
- Isolated nocturnal hypertension in relation to host and environmental factors and clock genes.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Disturbances of circadian profile and blood pressure control in patients with systemic lupus erythematosus without overt heart disease.Postepy dermatologii i alergologii · 2022Article
- Isolated Nocturnal Hypertension in Children.Frontiers in pediatrics · 2022Review
- Clinical risk factors and predictive score for the non-dipper profile in hypertensive patients: a case-control study.Clinical hypertension · 2021Article
- Isolated nocturnal hypertension: an unsolved problem-when to start treatment and how low should we go?Journal of human hypertension · 2020Article
- The Role of Nocturnal Blood Pressure and Sleep Quality in Hypertension Management.European cardiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nocturnal hypertension has been recognized as a significant risk factor for cardio- and cerebrovascular diseases. Blood pressure (BP) monitoring significantly increased our awareness of nocturnal hypertension and studies revealed its influence on target organ damage. Nocturnal hypertension is associated with nonphysiological 24-h BP patterns, which consider inadequate drop or even increment of nighttime BP in comparison with daytime BP (nondipping and reverse dipping). Nevertheless, investigations showed that nocturnal hypertension was a predictor of adverse outcome independently of circadian BP pattern. There are still many uncertainties regarding diagnosis, mechanisms and treatment of nocturnal hypertension. There is a small difference between American and European guidelines in cutoff values defining nocturnal hypertension. Pathophysiology is also not clear because many conditions such as diabetes, metabolic syndrome, obesity, sleep apnea syndrome, and renal diseases are related to nocturnal hypertension and nonphysiological circadian BP pattern, but mechanisms of nocturnal hypertension still remain speculative. Therapeutic approach is another important issue and chronotherapy provided the best results so far. There are studies which showed that some groups of antihypertensive medications are more effective in regulation of nocturnal BP, but it seems that the timing of drug administration has a crucial role in the reduction of nighttime BP and conversion of circadian patterns from nonphysiologic to physiologic. Follow-up studies are necessary to define clinical benefits of nocturnal BP reduction and restoring unfavorable 24-h BP variations to physiological variant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.