ArticleInternational journal of nanomedicine2020
Remineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Color change of tooth-colored restorative materials bonded to silver diamine fluoride-treated dentine: a systematic review.BMC oral health · 2024Pooled it
- Antibacterial effect and impact on caries activity of nanosilver fluoride and silver diamine fluoride in dentin caries of primary teeth: a randomized controlled clinical trial.BMC oral health · 2022Trial
- Effect of nanosilver fluoride versus silver diamine fluoride on shear bond strength and color change of resin-modified glass ionomer cement bonded to artificial dentin caries: an in-vitro study.BMC oral health · 2026Article
- Comparative Efficacy of Silver Diamine Fluoride and Sodium Fluoride in Managing Early Childhood Caries: An Updated Systematic Review and Meta-Analysis.International journal of dentistry · 2026Review
- Modulating silver diamine fluoride chemical derivatives by solid-binding peptides.Frontiers in bioengineering and biotechnology · 2026Article
- Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth.Scientific reports · 2025Article
- Preventing dentin erosion with silver diamine fluoride and salivary pellicle: an in vitro study.Clinical oral investigations · 2024Article
- Synthesis and Application of Silver Nanoparticles for Caries Management: A Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Remineralizing effect of NSF on artificial enamel caries.BMC oral health · 2024Article
- Evaluation of staining potential of Silver Diamine Fluoride, Potassium Iodide, Nanosilver Fluoride: an in vitro study.BMC oral health · 2024Article
- Comparative Evaluation of the Mechanical Efficiency of Nanosilver Fluoride and Sodium Fluoride Varnish: AnInternational journal of clinical pediatric dentistry · 2024Article
- Evaluation of resin infiltration for inhibiting initial caries progression: AnThe Saudi dental journal · 2024Article
- Silver Compounds for Caries Management.International dental journal · 2024Review
- Influence of silver fluoride plus potassium iodine on adhesive properties of primary carious dentin-resin interface: An in vitro study.The Saudi dental journal · 2024Article
- Effect of silver diamine fluoride/potassium iodide treatment on the prevention of dental erosion in primary teeth: an in vitro study.BDJ open · 2023Article
- The Effect of Nanosilver Sodium Fluoride on the Mechanical and Physiochemical Properties of Artificially Demineralised Dentin.Oral health & preventive dentistry · 2023Article
- Review
- Bioactive Materials for Caries Management: A Literature Review.Dentistry journal · 2023Review
- Evaluation of the remineralizing capacity of silver diamine fluoride on demineralized dentin under pH-cycling conditions.Journal of applied oral science : revista FOB · 2023Article
- Effect of silver nanoparticles associated with fluoride on the progression of root dentin caries in vitro.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries. MATERIALS AND
methodsDemineralized human dentine blocks were allocated to three groups. The blocks in group 1 underwent a topical application of a 12% silver diamine fluoride (SDF, 14,150 ppm fluoride) solution. The blocks in group 2 received a topical application of a 2.5% NaF (11,310 ppm fluoride) with PEG-AgNPs (400 ppm silver). The blocks in group 3 received deionized water. All blocks were subjected to pH cycling for 8 days. The surface morphology and cross-sectional features were investigated using scanning electron microscopy (SEM). The color parameters, crystal characteristics, lesion depth, and collagen degradation of the blocks were assessed using digital spectrophotometry, X-ray diffraction (XRD), micro-computed tomography, and spectrophotometry with a hydroxyproline assay, respectively.
resultsThe SEM showed that dentine collagen was exposed in group 3 but not in groups 1 and 2. The mean lesion depths in groups 1 to 3 were 118±7 µm, 121±14 µm, and 339±20 µm, respectively (groups1,2<3; p<0.001). The data indicated that fluoridated PEG-AgNPs introduced no significant color effect on dentine, but SDF caused distinct discoloration. The XRD indicated that silver chloride was formed in group 1, and fluorapatite was detected in groups 1 and 2. The concentration of hydroxyproline liberated from collagen was significantly less in groups 1 and 2 than in group 3.
conclusionThe use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.