Evidence map›Paper›PMID 32368049›Full record

ArticleInternational journal of nanomedicine2020

Antigen-Conjugated Silica Solid Sphere as Nanovaccine for Cancer Immunotherapy.

Ying Dong, Jing Gao, Mengyue Pei, Xiaoli Wang, Chuangnian Zhang, Yingjie Du, Yanjun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. ACS applied nano materials · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying DongSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, People's Republic of China.
Jing GaoSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, People's Republic of China.
Mengyue PeiTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, People's Republic of China.
Xiaoli WangTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, People's Republic of China.ORCID 0000-0003-3136-9807
Chuangnian ZhangTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, People's Republic of China.
Yingjie DuSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, People's Republic of China.
Yanjun JiangSchool of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanocarriers could deliver significantly higher amounts of antigen to antigen-presenting cells (APCs), which have great potential to stimulate humoral and cellular response in cancer immunotherapy. Thereafter, silica solid nanosphere (SiO MATERIALS AND

methodsSiO

resultsAll results indicated the successful covalent conjugation of OVA on the surface of SiO

conclusionThe as-prepared SiO

Indexed as

Adjuvants, ImmunologicAnimalsAntigen PresentationAntigensCancer VaccinesDendritic CellsDrug CarriersFemaleImmunotherapyMiceMice, Inbred C57BLNanospheresOligodeoxyribonucleotidesOvalbuminRAW 264.7 CellsSilicon DioxideAdjuvants, ImmunologicAntigensCancer VaccinesCPG-oligonucleotideDrug CarriersOligodeoxyribonucleotidesOvalbuminSilicon Dioxideantigen deliverycancer immunotherapynanovaccinesilica solid sphere

Identifiers

PMID32368049
PMCPMC7184137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.