Evidence map›Paper›PMID 32367788›Full record

ArticleJournal of psychosocial oncology

Trajectories and predictors of stress and depressive symptoms in spousal and intimate partner cancer caregivers.

Qi Chen, Lauren Terhorst, David A Geller, Wallis Marsh, Michael Antoni, Mary Amanda Dew, Michelle Biala, Josh Weinstein, Allan Tsung, Jennifer Steel

Abstract read
In one paragraph

Article in Journal of psychosocial oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cancer patient distress and health service use is linked with carer distress: evidence from a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  5. Exploring the role of psychological flexibility in relationship functioning among couples coping with prostate cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi ChenDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-1959-1854
Lauren TerhorstDepartment of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6376-1470
David A GellerDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Wallis MarshDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael AntoniDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
Mary Amanda DewDepartments of Psychiatry, Psychology, Epidemiology, and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4666-1870
Michelle BialaDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Josh WeinsteinDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Allan TsungDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jennifer SteelDepartments of Surgery, Psychiatry, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-9520-963X

Funding

Comprehensive Electronic Support System for Treatment of Cancer-Related SymptomsK07CA118576 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEEL, JENNIFER L. · 2006 to 2010
$757k
NCI NIH HHS K07 CA118576
6 · The paper itself

Abstract

purposeThe objective of the study is to investigate trajectories of stress and depressive symptoms of spousal and intimate partner caregivers in the context of cancer. We also examined the patient-related predictors of caregiver stress and depression.

designThis is a longitudinal cohort study.

participantsPatients diagnosed with cancers affecting the hepatobiliary and pancreatic system and their spousal or intimate partner caregivers were recruited at a large tertiary cancer center.

methodsThe patients and caregivers were assessed for their level of stress, depressive symptoms, relationship quality, and quality of life at the time of the patients' diagnosis, every 2 months for 12 months and then at 18 months.

findingsOne hundred and seventy-nine caregivers were included in the trajectory analyses. Amongst the 179 caregivers, 120 patient and caregiver dyads had complete data at baseline to 6-months. The majority of the spousal caregivers were female (84%) and the mean age was 57 years. 25% of caregivers reported high levels of chronic depressive symptoms. However, significant reductions were observed at 6 months. High and moderate levels of caregiver stress were also reported in 21% and 36% of caregivers, respectively. The caregivers who reported moderate levels of stress had a decrease in stress over time while those in the high stress group reported stable levels of stress over time. Caregivers' stress is predicted by the cancer patients' depressive symptoms but not patients' quality of life.

conclusionsCaregivers who reported high levels of stress and depressive symptoms at patients' cancer diagnosis remain high even after the initial adjustment. A bidirectional relationship between the caregivers' stress and the patients' depressive symptoms was observed. IMPLICATIONS: The development of dyadic interventions focusing on the patients' and caregivers' distress is warranted to decrease psychological morbidities of the dyad.

Indexed as

AdultAgedAged, 80 and overCaregiversDepressionFemaleHumansInterpersonal RelationsLongitudinal StudiesMaleMiddle AgedNeoplasmsRisk FactorsSexual PartnersStress, Psychologicalcancer caregiverdepressiondyadic functioningquality of lifestress

Identifiers

PMID32367788
PMCPMC7483918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.