Evidence map›Paper›PMID 32367730›Full record

Trial reportCirculation. Genomic and precision medicine2020

Alcohol Consumption and Cardiovascular Disease: A Mendelian Randomization Study.

Susanna C Larsson, Stephen Burgess, Amy M Mason, Karl Michaëlsson

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  10. Alcohol Consumption and Cardiovascular Health.The American journal of medicine · 2022
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susanna C LarssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden (S.C.L., K.M.).
Stephen BurgessDepartment of Public Health and Primary Care, and MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom (S.B.).
Amy M MasonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (A.M.M.).
Karl MichaëlssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden (S.C.L., K.M.).

Funding

Medical Research Council MC_UU_00002/7Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

backgroundThe causal role of alcohol consumption for cardiovascular disease remains unclear. We used Mendelian randomization (MR) to predict the effect of alcohol consumption on 8 cardiovascular diseases.

methodsUp to 94 single-nucleotide polymorphisms were used as instrumental variables for alcohol consumption. Genetic association estimates for cardiovascular diseases were obtained from large-scale consortia and UK Biobank. Analyses were conducted using the inverse variance-weighted, weighted median, MR-PRESSO, MR-Egger, and multivariable MR methods.

resultsGenetically predicted alcohol consumption was consistently associated with stroke and peripheral artery disease across the different analyses. The odds ratios (ORs) per 1-SD increase of log-transformed alcoholic drinks per week were 1.27 ([95% CI, 1.12-1.45]

conclusionsThis study provides evidence of a causal relationship between higher alcohol consumption and increased risk of stroke and peripheral artery disease. The causal role of alcohol consumption for other cardiovascular diseases requires further research.

Indexed as

Polymorphism, Single NucleotideAlcohol DrinkingCardiovascular DiseasesFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle Agedalcohol drinkingcardiovascular diseasescoronary artery diseaseodds ratioperipheral artery diseasestroke

Identifiers

PMID32367730
PMCPMC7299220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.