ArticleTurkish journal of ophthalmology2020
Can Complete Blood Count Parameters Predict Retinopathy of Prematurity?
Article in Turkish journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Biomarkers in retinopathy of prematurity: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- From Blood Count Parameters to ROP Risk: Early Hematological Predictors in Preterm Infants.Medicina (Kaunas, Lithuania) · 2025Article
- Prediction of retinopathy of prematurity development and treatment need with machine learning models.BMC ophthalmology · 2025Article
- Red blood cell parameters as biomarkers of retinopathy of prematurity in preterm infants born before 30 weeks of gestation.Scientific reports · 2025Article
- Predictive value of serum inflammatory markers in retinopathy of prematurity.Eye (London, England) · 2024Article
- Progress in the study of association between hematological indicators and retinopathy of prematurity (Review).Biomedical reports · 2024Review
- Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Platelet count and retinopathy of prematurity, a systematic review and meta-analysis.Frontiers in pediatrics · 2024Review
- Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity-A Multicenter Portuguese Cohort Study.International journal of molecular sciences · 2023Article
- Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023Review
- Commentary: Predicting need for treatment in retinopathy of prematurity - The elusive Holy Grail.Indian journal of ophthalmology · 2022Article
- Clinical parameters in different stages, zones, and remission/progression statuses of retinopathy of prematurity.Caspian journal of internal medicine · 2022Article
- The Role of Thrombocyte Parameters in Retinopathy of Prematurity Development.International journal of clinical practice · 2022Article
- Novel Potential Biomarkers for Retinopathy of Prematurity.Frontiers in medicine · 2022Review
- Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity.Indian journal of ophthalmology · 2021Article
- Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity.International journal of environmental research and public health · 2021Article
- Red cell distribution width and its association with retinopathy of prematurity.International ophthalmology · 2021Article
- Does First Blood Draw Matter in Retinopathy of Prematurity: A Comparative Analysis of Inflammation and Hypoxia-Related Parameters.Romanian journal of ophthalmologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To predict the risk of retinopathy of prematurity (ROP) development according to routine complete blood count (CBC) parameters. Materials and Methods: The medical records and CBC results of 150 premature neonates were retrospectively evaluated. As ROP develops 1 month after birth, first month CBC profiles of neonates without ROP (non-ROP), with ROP (ROP group), and those with Type 1, Type 2, and Stage 1+2 ROP were compared. Besides known statistical methods like Student's t-test, logistic regression and classification & regression tree (C&RT) analysis were also done to identify a reliable quantitative predictive parameter. Results: Mean gestational age and birth weight of the ROP group (n=99) and non-ROP (n=43) group were 29.39±3.43 and 32.05±2.20 weeks and 1382.44±545.30 and 1691.51±360.84 grams, respectively (p<0.001, p<0.001). Average hemoglobin (Hb) (p<0.001), hematocrit (HCT) (p<0.001), erythrocyte (p=0.005), mean corpuscular hemoglobin (MCH) (p=0.020), and MCH concentration (p=0.019) values of the ROP group were lower than those of the non-ROP group. Leukocyte was higher in the ROP group (p=0.018). Hb [odds ratio (OR)=0.668, 95% confidence interval (CI)=0.555-0.804, p<0.001], red cell distribution width (RDW) (OR=1.282, 95% CI=1.012-1.624, p=0.040), leukocyte (OR=1.157, 95% CI=1.053-1.271, p=0.002), and platelet (OR=0.997, 95% CI: 0.994-0.999, p=0.036) values differed significantly between the two groups. Platelet, MCV, and MCH parameters were found to be lower in the Type 1 ROP group compared to the Stage 1+2 ROP group (p<0.005). MCH was the most prominent predictor (cut-off: 34.43 pg) according to the results of C&RT analysis. Conclusion: As Hb plays an important role in oxygen transport, low levels of Hb and especially MCH may cause increased vascular endothelial growth factor secretion from the hypoxic retina, thereby causing ROP. Therefore, the results of this study are encouraging regarding the use of the abovementioned CBC parameters as a simple screening test to predict ROP.
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