ArticleJournal of thrombosis and haemostasis : JTH2020
Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Pooled it
- Ferroptosis in heatstroke: Mechanisms and therapeutic perspectives (Review).International journal of molecular medicine · 2026Review
- Heat stroke and the liver: mechanisms of injury and therapeutic strategies.European journal of medical research · 2026Review
- Cell death mechanisms in heat stroke and sepsis: ZBP1 and caspase-11 as molecular sensors driving the MLKL/GSDMD death execution axis.Frontiers in cell and developmental biology · 2026Review
- Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke.Acta pharmaceutica Sinica. B · 2026Article
- Heat stress-induced mitochondrial damage and its impact on leukocyte function.Journal of intensive care · 2025Review
- Heat Stress-Mediated Multi-Organ Injury: Pathophysiology and Treatment Strategies.Comprehensive Physiology · 2025Review
- Identification of liver proteins as biomarker for postmortem diagnosis of heat stroke through proteomics.Scientific reports · 2025Article
- Public knowledge, attitudes, and practices toward heat stroke in Ningbo, China: a cross-sectional study.Frontiers in public health · 2025Article
- Analysis of clinical characteristics and risk factors for patients with heat stroke in western China in 2022: a multicenter retrospective study.Frontiers in medicine · 2025Article
- Thrombomodulin Improves Cognitive Deficits in Heat-Stressed Mice.The international journal of neuropsychopharmacology · 2024Article
- A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Article
- Inflammation, coagulation, and cellular injury in heat-induced shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- ZBP1 and heatstroke.Frontiers in immunology · 2023Review
- Article
- Investigation of SARS-CoV-2 Variants and Their Effect on SARS-CoV-2 Monoclonal Antibodies, Convalescent and Vaccine Plasma by a Novel Web Tool.Diagnostics (Basel, Switzerland) · 2022Article
- Biomarkers of heatstroke-induced organ injury and repair.Experimental physiology · 2022Review
- A Potential Driver of Disseminated Intravascular Coagulation in Heat Stroke Mice: Neutrophil Extracellular Traps.International journal of environmental research and public health · 2022Article
- Heatstroke-induced coagulopathy: Biomarkers, mechanistic insights, and patient management.EClinicalMedicine · 2022Review
- Mortality Prediction Utilizing Blood Biomarkers to Predict the Severity of COVID-19 Using Machine Learning Technique.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundImmune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear.
objectivesWe sought to understand the effect of immune challenge on heat stroke pathology. PATIENTS/
methodsUsing a mouse model of classic heat stroke, we examined the impact of prior viral or bacterial infection on hematological aspects of recovery. Mice were exposed to heat either 48 or 72 hours following polyinosinic:polycytidylic acid (poly I:C) or lipopolysaccharide injection, time points when symptoms of illness (fever, lethargy, anorexia) were minimized or completely absent.
resultsEmploying multivariate supervised machine learning to identify patterns of molecular and cellular markers associated with heat stroke, we found that prior viral infection simulated with poly I:C injection resulted in heat stroke presenting with high levels of factors indicating coagulopathy. Despite a decreased number of platelets in the blood, platelets are large and non-uniform in size, suggesting younger, more active platelets. Levels of D-dimer and soluble thrombomodulin were increased in more severe heat stroke, and in cases of the highest level of organ damage markers D-dimer levels dropped, indicating potential fibrinolysis-resistant thrombosis. Genes corresponding to immune response, coagulation, hypoxia, and vessel repair were up-regulated in kidneys of heat-challenged animals; these correlated with both viral treatment and distal organ damage while appearing before discernible tissue damage to the kidney itself.
conclusionsHeat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.