Evidence map›Paper›PMID 32367464›Full record

ArticleJournal of endocrinological investigation2021

Effects of glucose variability on hematopoietic stem/progenitor cells in patients with type 1 diabetes.

F Boscari, M D'Anna, B M Bonora, S Tresso, R Cappellari, A Avogaro, D Bruttomesso, G P Fadini

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Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Bone marrow vasculature advancedFrontiers in cardiovascular medicine · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Glucose Variability: How Does It Work?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

F BoscariDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
M D'AnnaDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
B M BonoraDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy. benedettam.bonora@gmail.com.ORCID http://orcid.org/0000-0002-6770-2723
S TressoDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
R CappellariDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
A AvogaroDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
D BruttomessoDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
G P FadiniDepartment of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDiabetes reduces the levels of hematopoietic stem/progenitor cells (HSPCs), which can contribute to organ and tissue homeostasis. Among patients with diabetes, lower HSPC levels predict the development or worsening of micro- and macro-angiopathy. High glucose variability is also associated with diabetic complications and we have previously shown that acute hypoglycaemia can stimulate stem/progenitor cells. Thus, we evaluated the relationship between glucose variability or time in hypoglycaemia and HSPCs in patients with type 1 diabetes (T1D).

methodsPatients with T1D were compared to healthy subjects. HSPCs (CD34

resultsForty-four patients with T1D and 44 healthy subjects were enrolled. Compared to healthy controls, T1D patients had significantly lower levels of HSPCs and duration of diabetes was inversely correlated with HSPC levels. Significant direct correlations were found between HSPC levels and the coefficient of variation of glucose levels or time in hypoglycaemia, which were stronger in patients with short-term than in those with long-standing diabetes.

conclusionThis study confirms the pauperization of HSPCs in T1D patients and demonstrates a potential HSPC-stimulatory effect of hypoglycaemia, which mitigates with long-lasting diabetes. These data are consistent with a model whereby disease chronicity progressively blunts the release of HSPCs in response to adrenergic triggers, like hypoglycaemic events.

Indexed as

Bone Marrow CellsCase-Control StudiesCells, CulturedDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlucoseHematopoietic Stem CellsHumansMaleMiddle AgedPrognosisGlucoseContinuous glucose monitoringEndothelial progenitor cellsFlash glucose monitoring systemGlucose variabilityHematopoietic stem/progenitor cellsType 1 diabetes

Identifiers

PMID32367464
OpenAlexW3022659991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.