ReviewFrontiers of medicine2020
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain.
Review in Frontiers of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Neurological manifestations in coronavirus disease 2019 (COVID-19) patients: a systematic review of literature.CNS spectrums · 2022Pooled it
- Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings.BMC infectious diseases · 2021Pooled it
- Neurological Symptoms, Comorbidities, and Complications of COVID-19: A Literature Review and Meta-Analysis of Observational Studies.European neurology · 2021Pooled it
- Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis.European journal of radiology · 2020Pooled it
- Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19.Journal of virology · 2025Article
- Translating animal models of SARS-CoV-2 infection to vascular, neurological and gastrointestinal manifestations of COVID-19.Disease models & mechanisms · 2025Review
- Pathological Sequelae of SARS-CoV-2: A Review for Clinicians.The Yale journal of biology and medicine · 2024Review
- Neurological Complications of COVID-19: Unraveling the Pathophysiological Underpinnings and Therapeutic Implications.Viruses · 2024Review
- The anti-COVID-19 drug Paxlovid crosses biological barriers of the placenta and brain in rats.Npj viruses · 2024Article
- Dementia and epilepsy following COVID-19 infection in a 25-year-old female: A case report.Clinical case reports · 2024Article
- SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic.Microorganisms · 2023Review
- Assessment and Therapeutic Modulation of Heart Rate Variability: Potential Implications in Patients with COVID-19.Journal of cardiovascular development and disease · 2023Review
- Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19.Cellular and molecular neurobiology · 2023Review
- Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID.Biology · 2023Article
- Article
- Coronavirus Disease: Subacute to Chronic Neuroimaging Findings.Neuroimaging clinics of North America · 2023Review
- SARS-CoV-2 Possible Etiology of Cerebral Venous Thrombosis in a Teenager: Case Report and Review of Literature.Viruses · 2023Review
- Effects of COVID-19 on Synaptic and Neuronal Degeneration.Brain sciences · 2023Review
- Attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric manifestations of post-COVID syndrome.Frontiers in neuroscience · 2023Review
- An online survey on clinical characteristics of otologic symptoms linked to COVID-19 infection.Frontiers in public health · 2023Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has caused a global pandemic in only 3 months. In addition to major respiratory distress, characteristic neurological manifestations are also described, indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain. Based on previous studies of neuroinvasive human respiratory coronaviruses, it is proposed that after physical contact with the nasal mucosa, laryngopharynx, trachea, lower respiratory tract, alveoli epithelium, or gastrointestinal mucosa, SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release, tissue damage, and high neurosusceptibility to COVID-19, especially in the hypoxic conditions caused by lung injury. In some immune-compromised individuals, the virus may invade the brain through multiple routes, such as the vasculature and peripheral nerves. Therefore, in addition to drug treatments, such as pharmaceuticals and traditional Chinese medicine, non-pharmaceutical precautions, including facemasks and hand hygiene, are critically important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.