ArticleEuropean radiology2020
Impact of spectral body imaging in patients suspected for occult cancer: a prospective study of 503 patients.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Practical applications of photon-counting CT in oncology: an organ-based pictorial review.Insights into imaging · 2026Article
- Seeing the invisible: practical strategies to maximize the clinical impact of photon-counting CT in abdominal imaging.Abdominal radiology (New York) · 2026Review
- Follow-up recommendation rates with abdominopelvic photon counting CT: comparison with conventional dual-energy and single-energy CT.Abdominal radiology (New York) · 2026Article
- Comparison of iodine quantification accuracy on prototype deep silicon photon-counting and energy-integrating detector CT.Abdominal radiology (New York) · 2026Article
- The clinical applications of dual-layer spectral detector CT in digestive system diseases.European radiology · 2025Review
- Preliminary Study on the Evaluation Value of Extracellular Volume Fraction in the Pathological Grading of Lung Invasive AdenocarcinomaCurrent medical imaging · 2025Article
- Photon counting CT clinical adoption, integration, and workflow.Abdominal radiology (New York) · 2024Review
- Recent Breakthroughs in PET-CT Multimodality Imaging: Innovations and Clinical Impact.Bioengineering (Basel, Switzerland) · 2024Review
- Dual-energy CT improves differentiation of non-hypervascular pancreatic neuroendocrine neoplasms from CA 19-9-negative pancreatic ductal adenocarcinomas.La Radiologia medica · 2024Article
- Extracellular volume fraction as a potential predictor to differentiate lung cancer from benign lung lesions with dual-layer detector spectral CT.Quantitative imaging in medicine and surgery · 2023Article
- Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT.BMC medical imaging · 2023Article
- Diagnosis of benign and malignant thyroid nodules by a dual-layer spectral detector CT-based nomogram.Frontiers in oncology · 2023Article
- Spectral CT in peritoneal carcinomatosis from ovarian cancer: a tool for differential diagnosis of small nodules?European radiology experimental · 2022Article
- Improving radiation physics, tumor visualisation, and treatment quantification in radiotherapy with spectral or dual-energy CT.Journal of applied clinical medical physics · 2022Review
- Economic impact of spectral body imaging in diagnosis of patients suspected for occult cancer.Insights into imaging · 2021Article
- Comparison of contrast-enhanced CT, dual-layer detector spectral CT, and whole-body MRI in suspected metastatic breast cancer: a prospective diagnostic accuracy study.European radiology · 2021Article
- Building a dual-energy CT service line in abdominal radiology.European radiology · 2021Review
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5 authors.
Funding
Abstract
objectivesTo investigate the diagnostic impact and performance of spectral dual-layer detector CT in the detection and characterization of cancer compared to conventional CE-CT.
methodsIn a national workup program for occult cancer, 503 patients (286 females and 217 males) were prospectively enrolled for a contrast-enhanced spectral CT scan. The readings were performed with and without spectral data available. A minimum of 3 months between interpretations was implemented to minimize recall bias. The sequence of reads for the individual patient was randomized. Readers were blinded for patient identifiers and clinical outcome. Two radiologists with 9 and 33 years of experience performed the readings in consensus. If disagreement, a third radiologist with 11 years of experience determined the outcome of the reading
resultsSignificantly more cancer findings were identified on the spectral reading. In 73 cases of proven cancer, we found a sensitivity of 89% vs 77% and a specificity of 77% vs 83% on spectral CT compared to conventional CT. A slight increase in reading time in spectral images of 82 s was found (382 vs 300, p < 0.001). For all cystic lesions, the perceived diagnostic certainty increased from 30% being completely certain to 96% most pronounced in the kidney, liver, thyroid, and ovaries. And adding the spectral information to the reading gave a decrease in follow-up examination for diagnostic certainty (0.25 vs 0.81 per reading, p < 0.001).
conclusionThe use of contrast-enhanced spectral CT increases the confidence of the radiologists in correct characterization of various lesions and minimizes the need for supplementary examinations. KEY POINTS: • Spectral CT is associated with a higher sensitivity, but a slightly lower specificity compared to conventional CT. • Spectral CT increases the confidence of the radiologists. • The need for supplementary examinations is decreased, with only a slight increase in reading times.
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