Evidence map›Paper›PMID 32367248›Full record

ArticleDigestive diseases and sciences2021

Low Epstein-Barr Virus Prevalence in Cardia Gastric Cancer Among a High-Incidence Chinese Population.

John G Aversa, Minkyo Song, Nan Hu, Alisa M Goldstein, Stephen M Hewitt, Margaret L Gulley, Sanford Dawsey, Maria Constanza Camargo, Philip R Taylor, Charles S Rabkin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

John G AversaSurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. aversaj@gmail.com.
Minkyo SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E204, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Nan HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 7E236, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E438, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, 10/3N252, Bethesda, MD, 20892, USA.
Margaret L GulleyLaboratory Medicine, Department of Pathology, University of North Carolina, 160 Medical Drive, 913 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.
Sanford DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E302, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Maria Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E338, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E320, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Room 6E110, 9609 Medical Center Drive, Rockville, MD, 20892-9776, USA.
National Institutes of Health · USNational Cancer Institute · USCenter for Cancer Research · USUniversity of North Carolina at Chapel Hill · US

Funding

Experimental Pathology Laboratory (EPL)ZICBC011638 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HEWITT, STEPHEN · 2015 to 2025
$16.6M
Molecular mechanisms of infection-related cancerZIACP010212 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$4.6M
Division of Cancer Epidemiology and Genetics, National Cancer Institute Intramural Research ProgramIntramural NIH HHS ZIA CP010212
6 · The paper itself

Abstract

backgroundEpstein-Barr virus (EBV) positivity is associated with better gastric cancer prognosis and is found in a relatively fixed 9% of tumors worldwide.

aimWe aimed to examine the EBV status of gastric adenocarcinomas in a very high-incidence population and to compare prevalence between cardia and non-cardia anatomic subsites.

methodsWe evaluated 1035 adult gastric adenocarcinoma cases presenting during 1997-2005 to the Shanxi Cancer Hospital in Taiyuan, Shanxi Province, China. EBV-encoded RNA was detected in alcohol-fixed paraffin-embedded tumor specimens by in situ hybridization. Associations were assessed in case-case comparisons using the Chi-squared test for categorical variables and the Mann-Whitney U test for continuous variables, with p values < 0.05 considered statistically significant. Adjusted odds ratios were calculated using logistic regression, and mortality hazard ratios (HRs) were estimated by Cox proportional hazards regression.

resultsSixty-four percent of the evaluated cancers were found in the cardia. Cardia tumor localization was associated with male sex, advanced primary tumor stage, better differentiated histology, and intestinal-type Lauren classification. Four percent of the non-cardia and only 0.9% of cardia cancers were EBV-positive. EBV positivity was associated with better overall survival (adjusted HR 0.30, 95% CI 0.14-0.63).

conclusionsOur study highlights unusually low EBV prevalence in gastric adenocarcinoma among a high-incidence population, particularly for cardia cancers. These findings suggest a unique risk factor profile for the high incidence of gastric cancer in this population.

Indexed as

CardiaPopulation SurveillanceAdenocarcinomaAgedChinaEpstein-Barr Virus InfectionsFemaleHumansIncidenceMaleMiddle AgedPrevalenceStomach NeoplasmsCardiaEpstein–Barr virusGastric cancerShanxi

Identifiers

PMID32367248
PMCPMC7685001
OpenAlexW3022852803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.