Trial reportScientific reports2020
Genetic basis of sleep bruxism and sleep apnea-response to a medical puzzle.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06457646 (mRNA Expression and Genetic Polymorphisms Affecting DRD3), which is not on this map. Cited by 72 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism
Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- The impact of continuous positive airway pressure combined with lifestyle intervention on patients with obstructive sleep apnea: a multilevel meta-analysis.Frontiers in medicine · 2026Pooled it
- Prevalence of bruxism in patients affected by epilepsy: a systematic review and meta-analysis.Acta odontologica Scandinavica · 2025Pooled it
- Genetics and sleep bruxism: a systematic review and meta-analysis of studies with twins.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.EBioMedicine · 2023Pooled it
- Polymorphisms of the serotonin receptors genes in patients with bruxism: a systematic review.Journal of applied oral science : revista FOB · 2022Pooled it
- Jaw Exercise Versus Jaw & Posture Exercise Therapies in Comparison to Occlusal Splint Effectiveness in Probable Sleep Bruxism: A Randomised Controlled Study.Journal of oral rehabilitation · 2025Trial
- Factors influencing the prediction of obstructive sleep apnea: an observational study from a developing country.Future science OA · 2026Article
- The COMT rs4680 SNP participates in the regulation of the arousal threshold in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Goldenhar Syndrome-Embryological, Anatomical, Etiopathogenic Mechanisms and Treatment of Obstructive Sleep Apnea.International journal of molecular sciences · 2026Review
- Sleep Bruxism, Pharmacotherapy, Sleep Aspects and Screen Use in Children and Adolescents With Down Syndrome: A Cluster Analysis.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism.BMC oral health · 2026Observational
- Bruxism Frequency and Low-Intensity Occlusal Tactile Detection in Healthy Adults.Journal of clinical medicine · 2026Article
- Exploring the Role of Nocturnal Hypoxemia and Sleep Fragmentation in Memory Decline: Insights From Explainable Machine Learning Models.The clinical respiratory journal · 2026Article
- Gut microbial metabolites, barrier dysfunction, and endotoxemia in men obstructive sleep apnea-associated hypertension.iScience · 2026Article
- Sleep Bruxism: Mapping Potential Direct and Indirect Risk Pathways in EPISONO Adult Population-Based Study.Journal of oral rehabilitation · 2026Article
- The Natural History of Obstructive Sleep Apnea: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- The importance of dopamine levels and single-nucleotide polymorphism withinAnnals of medicine · 2025Article
- Sleep Bruxism and Hypobaric Hypoxia Exposure: Exploring the Physiological Association.Journal of clinical medicine · 2025Review
- Artificial Intelligence-Driven Hemodynamic Monitoring of Simulated Bruxism Using Functional Near-Infrared Spectroscopy: A Preliminary Study.CNS neuroscience & therapeutics · 2025Article
- Short-Term Effects of Visceral Manual Therapy on Autonomic Nervous System Modulation in Individuals with Clinically Based Bruxism: A Randomized Controlled Trial.Dentistry journal · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep bruxism (SB) and obstructive sleep apnea (OSA) are co-occurring sleep conditions. The study aimed to evaluate the association of selected single-nucleotide polymorphisms (SNPs) occurring within the genes of the serotonin and dopamine pathways in SB and OSA and investigate the relationship between them. The study group included 100 Caucasian patients. SB and OSA were diagnosed in 74 and 28 patients, respectively. In addition, 125 unrelated Caucasian healthy blood donors served as randomly selected controls to enable comparison of polymorphisms. The following SNPs were analyzed: rs2770304 and rs6313 within the serotonin receptor encoding gene (HTR2A), rs4680 polymorphism of the catechol-O-methyltransferase (COMT) gene, and rs686 within the dopamine receptor (DRD1) encoding gene. The prevalence of the DRD1 rs686 G variant (GG homozygosity) was found to be high in the study group compared to the control group. Bruxism episode index (BEI) was found to be significantly increased in the HTR2A rs6313 TT homozygotes compared to the heterozygous patients. Moreover, within a group of the HTR2A rs2770304 TT homozygous cases, a statistically significant correlation was observed between BEI and apnea-hypopnea index. These results indicate that DRD1 rs686 may potentially affect predisposition to SB, that HTR2A rs6313 SNP may be involved in SB pathogenesis, and that HTR2A rs2770304 polymorphism might contribute to the association between SB and OSA. This suggests a possible genetic contribution to the etiology of primary SB.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.