Evidence map›Paper›PMID 32367004›Full record

ArticleEye (London, England)2021

Monitoring for neovascular age-related macular degeneration (AMD) reactivation at home: the MONARCH study.

Elizabeth Ward, Robin A Wickens, Abby O'Connell, Lucy A Culliford, Chris A Rogers, Eleanor A Gidman, Tunde Peto, Paul C Knox, Benjamin J L Burton, Andrew J Lotery and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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  13. Real-Life Value of the OdysightJournal of clinical medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Elizabeth WardBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Robin A WickensBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Abby O'ConnellBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Lucy A CullifordBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Chris A RogersBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Eleanor A GidmanBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK.
Tunde PetoCentre for Public Health, Queen's University of Belfast, Belfast, BT12 6BA, UK.ORCID http://orcid.org/0000-0001-6265-0381
Paul C KnoxDepartment of Eye and Vision Science, University of Liverpool, Liverpool, L7 8TX, UK.ORCID http://orcid.org/0000-0002-2578-7335
Benjamin J L BurtonJames Paget University Hospitals NHS Foundation Trust, Norfolk, NR31 6LA, UK.
Andrew J LoteryDepartment of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.ORCID http://orcid.org/0000-0001-5541-4305
Sobha SivaprasadNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK.
Michael DonnellyCentre for Public Health, Queen's University of Belfast, Belfast, BT12 6BA, UK.
Charlene TreanorCentre for Public Health, Queen's University of Belfast, Belfast, BT12 6BA, UK.
Ruth E HoggCentre for Public Health, Queen's University of Belfast, Belfast, BT12 6BA, UK. r.e.hogg@qub.ac.uk.
Barnaby C ReevesBristol Trials Centre (CTEU), University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK. barney.reeves@bristol.ac.uk.ORCID http://orcid.org/0000-0002-5101-9487
Bristol Royal Infirmary · GBQueen's University Belfast · GBJames Paget University Hospital · GBMoorfields Eye Hospital NHS Foundation Trust · GBUniversity of Liverpool · GBUniversity of Southampton · GB

Funding

Department of Health 15/97/02DH | NIHR | Health Technology Assessment Programme (NIHR Health Technology Assessment Programme) HTA Project:15/97/02
6 · The paper itself

Abstract

aimsThis study aims to quantify the diagnostic test-accuracy of three visual function self-monitoring tests for detection of active disease in patients with neovascular age-related macular degeneration (nAMD) when compared with usual care. An integrated qualitative study will investigate the acceptability of these home-based testing strategies.

methodsAll consenting participants are provided with an equipment pack containing an iPod touch with two vision test applications installed and a paper journal of reading tests. Participants self-monitor their vision at home each week with all three tests for 12-18 months. Usual care continues over this period. Key eligibility criteria are: age ≥50 years; at least one eye with AMD with ≥6-≤42 months since first AMD treatment; and vision not worse than Snellen 6/60, LogMAR 1.04 or 33 letters. The primary outcome, and reference standard, is diagnosis of active disease during usual care monitoring in the Hospital Eye Service. Secondary outcomes include duration of study participation, ability of participants to do the tests, adherence to weekly testing and acceptability of the tests to participants.

conclusionsRecruitment is in progress at five NHS centres. Challenges in procuring equipment, setting up the devices and transporting devices containing lithium batteries to participating sites delayed the start of recruitment. The study will describe the performance of the tests self-administered at home in detecting active disease compared to usual care monitoring. It will also describe the feasibility of the NHS implementing patient-administered electronic tests or similar applications at home for monitoring health.

Indexed as

Macular DegenerationWet Macular DegenerationHumansMiddle AgedVisual Acuity

Identifiers

PMID32367004
PMCPMC8027627
OpenAlexW3017504151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.