Evidence map›Paper›PMID 32366995›Full record

SynthesisEuropean journal of clinical nutrition2020

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.

Alex F Bullock, Sarah L Greenley, Gordon A G McKenzie, Lewis W Paton, Miriam J Johnson

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06730204 (Nutrition Strategies and Malnutrition Assessment Management Systems for Preventing Malnutrition in Children With Solid Tumors), which is not on this map. Cited by 169 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 14 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06730204 narecruitingnot on this mapstarted 2023, after this paper: background citation

Nutrition Strategies and Malnutrition Assessment Management Systems for Preventing Malnutrition in Children With Solid Tumors: an Exploratory Intervention Study

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2023 to 2026Enrolled400ConditionsTumor, Solid, Children, Nutritional InterventionArmsStandardized nutritional management, Standardized nutritional management + short peptide ONS
3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 14 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Pooled it
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  8. Fasting during cancer treatment: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
  9. GLIM-defined malnutrition and overall survival in cancer patients: A meta-analysis.JPEN. Journal of parenteral and enteral nutrition · 2023
    Pooled it
  10. Pooled it
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  15. Trial
  16. Effect of modified Baduanjin exercise on nutritional status in patients with nasopharyngeal carcinoma: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  17. Effect of individualized nutritional intervention on head and neck cancer patients receiving radiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  18. Trial
  19. Article
  20. Nutritional outcomes associated with enteral versus parenteral nutritional support during intensive induction chemotherapy for acute myeloid leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational

109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alex F BullockWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK. alex.bullock@hyms.ac.uk.ORCID http://orcid.org/0000-0002-4065-3925
Sarah L GreenleyAcademy of Primary Care, Hull York Medical School, University of Hull, Hull, UK.
Gordon A G McKenzieWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.
Lewis W PatonDepartment of Health Sciences, University of York, York, UK.
Miriam J JohnsonWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.
University of Hull · GBUniversity of York · GB

Funding

Yorkshire Cancer Research HEND405PhD
6 · The paper itself

Abstract

Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however the best screening tool for this group is unknown. The aim was to systematically review the published evidence regarding markers and measures of nutritional status in older adults with cancer (age ≥ 70). A systematic search was performed in Ovid Medline, EMBASE, Web of Science, CINAHL, British Nursing Database and Cochrane CENTRAL; search terms related to malnutrition, cancer, older adults. Titles, abstracts and papers were screened and quality-appraised. Data evaluating ability of markers of nutritional status to predict patient outcomes were subjected to meta-analysis or narrative synthesis. Forty-two studies, describing 15 markers were included. Meta-analysis found decreased food intake was associated with mortality (OR 2.15 [2.03-4.20] p = < 0.00001) in univariate analysis. Prognostic Nutritional Index (PNI) was associated with overall survival (HR 1.89 [1.03-3.48] p = 0.04). PNI markers (albumin, total lymphocyte count) could be seen as markers of inflammation rather than nutrition. There a suggested relationship between very low body mass index (BMI) (<18 kg/m

Indexed as

MalnutritionNeoplasmsAgedCachexiaHumansNutritional StatusNutrition Assessment

Identifiers

PMID32366995
PMCPMC7606134
OpenAlexW3022378533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.