ArticleNature plants2020
Structural insights into photoactivation and signalling in plant phytochromes.
Article in Nature plants, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Overcoming the Challenges of Producing Plant Phytochromes in Escherichia coli.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Optogenetic-Controlled iPSC-Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Distinct Protochromic Mechanisms Driving Green/Red Absorption in Phycocyanobilin-Binding Proteins.Biochemistry · 2025Article
- Pr and Pfr structures of plant phytochrome A.Nature communications · 2025Article
- Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B.Cell discovery · 2025Article
- The macromolecular crystallography beamlines of the Helmholtz-Zentrum Berlin at the BESSY II storage ring: history, current status and future directions.Journal of synchrotron radiation · 2025Article
- Integrated Study of Fluorescence Enhancement in the Y176H Variant of Cyanobacterial Phytochrome Cph1.Biochemistry · 2025Article
- Synergetic Contributions of High Quenching Concentration and Tuned Square Antiprism Geometry Boosting Far-Red Emission of EuAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases.Nature communications · 2024Article
- Molecular origins of absorption wavelength variation among phycocyanobilin-binding proteins.Biophysical journal · 2024Article
- Plant Phytochrome Interactions Decode Light and Temperature Signals.The Plant cell · 2024Article
- Expression, purification and crystallization of the photosensory module of phytochrome B (phyB) from Sorghum bicolor.Acta crystallographica. Section F, Structural biology communications · 2024Article
- Structural insights into plant phytochrome A as a highly sensitized photoreceptor.Cell research · 2023Article
- Plant phytochrome A in the Pr state assembles as an asymmetric dimer.Cell research · 2023Article
- The structure of Arabidopsis phytochrome A reveals topological and functional diversification among the plant photoreceptor isoforms.Nature plants · 2023Article
- Vibrational Spectroscopy of Phytochromes.Biomolecules · 2023Review
- Machine learning classification of plant genotypes grown under different light conditions through the integration of multi-scale time-series data.Computational and structural biotechnology journal · 2023Article
- The structural effect between the output module and chromophore-binding domain is a two-way street via the hairpin extension.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Improved fluorescent phytochromes for in situ imaging.Scientific reports · 2022Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant phytochromes are red/far-red photochromic photoreceptors that act as master regulators of development, controlling the expression of thousands of genes. Here, we describe the crystal structures of four plant phytochrome sensory modules, three at about 2 Å resolution or better, including the first of an A-type phytochrome. Together with extensive spectral data, these structures provide detailed insight into the structure and function of plant phytochromes. In the Pr state, the substitution of phycocyanobilin and phytochromobilin cofactors has no structural effect, nor does the amino-terminal extension play a significant functional role. Our data suggest that the chromophore propionates and especially the phytochrome-specific domain tongue act differently in plant and prokaryotic phytochromes. We find that the photoproduct in period-ARNT-single-minded (PAS)-cGMP-specific phosphodiesterase-adenylyl cyclase-FhlA (GAF) bidomains might represent a novel intermediate between MetaRc and Pfr. We also discuss the possible role of a likely nuclear localization signal specific to and conserved in the phytochrome A lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.