ArticleNature communications2020
Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication.iScience · 2026Article
- Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium.bioRxiv : the preprint server for biology · 2026Article
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism.iScience · 2025Article
- Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium.Stem cell research & therapy · 2025Article
- Article
- Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.International journal of molecular sciences · 2024Article
- Magnetic nanobead assisted the dual targets driven fluorescent biosensor based on SPEXPAR and MNAzyme for the olfactory marker protein detection.Materials today. Bio · 2024Article
- Global research Activity on olfactory marker protein (OMP): A bibliometric and visualized analysis.Heliyon · 2024Article
- Craniofacial and olfactory sensory changes after long-term unilateral nasal obstruction-an animal study using MMP-3-LUC transgenic rats.Scientific reports · 2024Article
- Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.Frontiers in neurology · 2024Article
- Human Olfactory Receptor Sensor for Odor Reconstitution.Sensors (Basel, Switzerland) · 2023Review
- A multivesicular body-like organelle mediates stimulus-regulated trafficking of olfactory ciliary transduction proteins.Nature communications · 2022Article
- Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.Molecular brain · 2022Article
- Olfactory marker protein is unlikely to be cleaved by calpain 5.Molecular brain · 2022Article
- Olfactory marker protein regulation of glucagon secretion in hyperglycemia.Experimental & molecular medicine · 2022Article
- Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.The Journal of clinical investigation · 2022Article
- Olfactory marker protein interacts with adenosine nucleotide derivatives.Biochemistry and biophysics reports · 2021Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor neurons (ORNs) use odour-induced intracellular cAMP surge to gate cyclic nucleotide-gated nonselective cation (CNG) channels in cilia. Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the odour-source searching behaviour requires ORNs to be sensitive to odours when approaching targets. How ORNs accommodate these conflicting aspects of cAMP responses remains unknown. Here, we discover that olfactory marker protein (OMP) is a major cAMP buffer that maintains the sensitivity of ORNs. Upon the application of sensory stimuli, OMP directly captured and swiftly reduced freely available cAMP, which transiently uncoupled downstream CNG channel activity and prevented persistent depolarization. Under repetitive stimulation, OMP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.