ArticleProceedings of the National Academy of Sciences of the United States of America2020
The origin and diversification of a novel protein family in venomous snakes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 102 citations in OpenAlex.
- The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nature's antivenom: Combinations of conserved rattlesnake serum metalloproteinase inhibitors block the lethal action of viper venoms.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.bioRxiv : the preprint server for biology · 2026Article
- Chromosome-level reference genome for the common wall gecko (Tarentola mauritanica) enables comparative and functional studies in geckos.G3 (Bethesda, Md.) · 2026Article
- The Golden Lancehead Genome Reveals Distinct Selective Processes Acting on Venom Genes of an Island Endemic Snake.Genome biology and evolution · 2026Article
- Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation.Scientifica · 2026Review
- Molecular mechanisms underlying early functional divergence in snake venom inferred from the genomes of two pitviper lineages.BMC biology · 2025Article
- Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- A Chromosome-level Genome Assembly of the Western Nose-Horned Viper (Vipera ammodytes ammodytes).Genome biology and evolution · 2025Article
- Unveiling the Evolutionary History of European Vipers and Their Venoms From a Multi-Omic Approach.Molecular ecology · 2025Article
- Duplication of a conserved mitochondrial enzyme gene arms parasitoid wasps with venom cytotoxicity and oogenesis regulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Life history and chromosome organization determine chemoreceptor gene expression in rattlesnakes.The Journal of heredity · 2025Article
- The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake.Genome biology · 2025Article
- A Segregating Structural Variant Defines Novel Venom Phenotypes in the Eastern Diamondback Rattlesnake.Molecular biology and evolution · 2025Article
- Chromosome-level reference genome for the medically important Arabian horned viper (Cerastes gasperettii).GigaScience · 2025Article
- Evolution of specialized toxin arsenals in a bacterial symbiont of arthropods.The ISME journal · 2025Article
- Article
- Exploring the Venom Gland Transcriptome ofToxins · 2024Article
- VenomCap: An exon-capture probe set for the targeted sequencing of snake venom genes.Molecular ecology resources · 2024Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The genetic origins of novelty are a central interest of evolutionary biology. Most new proteins evolve from preexisting proteins but the evolutionary path from ancestral gene to novel protein is challenging to trace, and therefore the requirements for and order of coding sequence changes, expression changes, or gene duplication are not clear. Snake venoms are important novel traits that are comprised of toxins derived from several distinct protein families, but the genomic and evolutionary origins of most venom components are not understood. Here, we have traced the origin and diversification of one prominent family, the snake venom metalloproteinases (SVMPs) that play key roles in subduing prey in many vipers. Genomic analyses of several rattlesnake (
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