Evidence map›Paper›PMID 32366656›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis.

Kopperuncholan Namachivayam, Krishnan MohanKumar, Darla R Shores, Sunil K Jain, Jennifer Fundora, Allen D Everett, Ling He, Hua Pan, Samuel A Wickline, Akhil Maheshwari

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  13. Gestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
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  14. Review
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  16. Succinate aggravates intestinal injury in mice with necrotizing enterocolitis.Frontiers in cellular and infection microbiology · 2022
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  17. Review
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  19. Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  20. Hemostatic Challenges in Neonates.Frontiers in pediatrics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kopperuncholan NamachivayamDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612; nkcholan@jhmi.edu akhil@jhmi.edu.
Krishnan MohanKumarDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Darla R ShoresDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-0551-7880
Sunil K JainDepartment of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555.
Jennifer FundoraDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Allen D EverettDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Ling HeDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Hua PanDivision of Cardiology, USF Heart Institute, University of South Florida, Tampa, FL 33629.
Samuel A WicklineDivision of Cardiology, USF Heart Institute, University of South Florida, Tampa, FL 33629.
Akhil MaheshwariDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612; nkcholan@jhmi.edu akhil@jhmi.edu.
Johns Hopkins University · USUniversity of South Florida · USThe University of Texas Medical Branch at Galveston · US

Funding

METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Institutional Training for PediatriciansT32HD044355 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BRADY, TAMMY MCLOUGHLIN · 2003 to 2023
$4.1M
Coactivator P300 promotes hepatic steatosis in obesityR01DK120309 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HE, LING, YU, LIQING · 2019 to 2023
$2.7M
Prevention and Treatment of Acute Kidney InjuryR01DK102691 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2015 to 2018
$2.0M
Activation of the cAMP-PKA pathway antagonizes metformin actionR01DK107641 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HE, LING · 2016 to 2020
$1.8M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL073646NHLBI NIH HHS R01 HL124078NHLBI NIH HHS R01 HL133022NICHD NIH HHS T32 HD044355NIDDK NIH HHS R01 DK102691NIDDK NIH HHS R01 DK107641NIDDK NIH HHS R01 DK120309
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and an orphan disease with no specific treatment. Most patients with confirmed NEC develop moderate-severe thrombocytopenia requiring one or more platelet transfusions. Here we used our neonatal murine model of NEC-related thrombocytopenia to investigate mechanisms of platelet depletion associated with this disease [K. Namachivayam, K. MohanKumar, L. Garg, B. A. Torres, A. Maheshwari,

Indexed as

AnimalsAnimals, NewbornBlood PlateletsDisease Models, AnimalEnterocolitis, NecrotizingHumansInfant, NewbornInfant, Newborn, DiseasesInflammationIntestinal DiseasesIntestinesMacrophagesMiceThrombinThrombocytopeniaThrombincoagulationinflammationintestinal

Identifiers

PMID32366656
PMCPMC7245134
OpenAlexW3021613507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.