Evidence map›Paper›PMID 32366574›Full record

ReviewInfection and immunity2020

Biting Off What Can Be Chewed: Trogocytosis in Health, Infection, and Disease.

Akhila Bettadapur, Hannah W Miller, Katherine S Ralston

Open access · greenAbstract readReview
In one paragraph

Review in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Hyperactive Rac converts sublethal to lethal trogocytosis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Hyperactive Rac converts sublethal nibbling to lethal phagocytosisbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Cross-species protection suggestsInfection and immunity · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Akhila Bettadapur *Department of Microbiology and Molecular Genetics, University of California, Davis, California, USA.
Hannah W Miller *Department of Microbiology and Molecular Genetics, University of California, Davis, California, USA.
Katherine S RalstonDepartment of Microbiology and Molecular Genetics, University of California, Davis, California, USA ksralston@ucdavis.edu.
University of California, Davis · US

Funding

The role of Entamoeba histolytica trogocytosis (trogo-: nibble) in the pathogenesis of amoebiasisR01AI146914 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RALSTON, KATHERINE S · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI146914
6 · The paper itself

Abstract

Trogocytosis is part of an emerging, exciting theme of cell-cell interactions both within and between species, and it is relevant to host-pathogen interactions in many different contexts. Trogocytosis is a process in which one cell physically extracts and ingests "bites" of cellular material from another cell. It was first described in eukaryotic microbes, where it was uncovered as a mechanism by which amoebae kill cells. Trogocytosis is potentially a fundamental form of eukaryotic cell-cell interaction, since it also occurs in multicellular organisms, where it has functions in the immune system, in the central nervous system, and during development. There are numerous scenarios in which trogocytosis occurs and an ever-evolving list of functions associated with this process. Many aspects of trogocytosis are relevant to microbial pathogenesis. It was recently discovered that immune cells perform trogocytosis to kill

Indexed as

Cell CommunicationHost-Pathogen InteractionsPhagocytosisAnimalsBacterial Physiological PhenomenaEmbryonic DevelopmentHumansImmune EvasionImmune SystemMembrane ProteinsOrgan SpecificityMembrane Proteinscell deathcomplementEntamoebaFrancisellamacrophagesneutrophilsphagocytosisTrichomonastrogocytosis

Identifiers

PMID32366574
PMCPMC7309612
OpenAlexW3023617975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.