Evidence map›Paper›PMID 32366485›Full record

ArticleThe European respiratory journal2020

Quality of life, tuberculosis and treatment outcome; a case-control and nested cohort study.

Sumona Datta, Robert H Gilman, Rosario Montoya, Luz Quevedo Cruz, Teresa Valencia, Doug Huff, Matthew J Saunders, Carlton A Evans

Open access · hybridAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Post-tuberculosis morbidities and their associated mortality: moving from challenges to solutions.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
  13. Article
  14. Review
  15. Journal of personalized medicine · 2022
    Review
  16. Article
  17. Clinical standards for the assessment, management and rehabilitation of post-TB lung disease.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Article
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Sumona DattaDept of Infectious Disease, Imperial College London, London, UK sumona.datta@ifhad.org.
Robert H GilmanDept of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-9037-0712
Rosario MontoyaIFHAD: Innovation for Health and Development, Laboratory for Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0001-8692-9475
Luz Quevedo CruzIFHAD: Innovation for Health and Development, Laboratory for Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
Teresa ValenciaIFHAD: Innovation for Health and Development, Laboratory for Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
Doug HuffDept of Infectious Disease, Imperial College London, London, UK.
Matthew J SaundersDept of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0003-3033-2367
Carlton A EvansDept of Infectious Disease, Imperial College London, London, UK.
Universidad Peruana Cayetano Heredia · PEJohns Hopkins University · US

Funding

Medical Research Council MR/K007467/1Medical Research Council MR/T040165/1Wellcome Trust 057434/Z/99/ZWellcome Trust 070005/Z/02/ZWellcome Trust 078340/Z/05/ZWellcome Trust 105788/Z/14/ZWellcome Trust 201251/Z/16/Z
6 · The paper itself

Abstract

backgroundGlobal tuberculosis policy increasingly emphasises broad tuberculosis impacts and highlights the lack of evidence concerning tuberculosis-related quality of life (QOL).

methodsParticipants were recruited in 32 Peruvian communities between July 13, 2016 and February 24, 2018 and followed-up until November 8, 2019. Inclusion criteria were age ≥15 years for "patients" (n=1545) starting treatment for tuberculosis disease in health centres; "contacts" (n=3180) who shared a patient's household for ≥6 h·week

findingsNewly diagnosed tuberculosis was most strongly associated with lower QOL scores (p<0.001). Patients initially had lower QOL than controls for all EUROHIS-QOL questions (p≤0.01), especially concerning health, ADL and self. Lower initial QOL in patients predicted adverse treatment outcomes and scores <13 points had 4.2-fold (95% CI 2.3-7.6) increased risk of death

conclusionsTuberculosis was associated with impaired psychosocioeconomic QOL which recovered with successful treatment. Low QOL scores predicted adverse treatment outcome. This brief EUROHIS-QOL eight-item questionnaire quantified the holistic needs of tuberculosis-affected people, potentially guiding patient-centred care.

Indexed as

Quality of LifeTuberculosis, Multidrug-ResistantActivities of Daily LivingAdolescentCase-Control StudiesCohort StudiesHumansTreatment Outcome

Identifiers

PMID32366485
PMCPMC7406858
OpenAlexW3020965728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.