ArticleCritical care (London, England)2020
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Kinetics of 5% and 20% albumin: A controlled crossover trial in volunteers.Acta anaesthesiologica Scandinavica · 2022Trial
- The Unknown Benefits of Dermal Matrices in Prevent Loss of Albumin in Patient with Major Burns.European burn journal · 2026Article
- Albumin 20% in surgical and critically ill patients; a comprehensive review.Critical care (London, England) · 2026Review
- Where does the fluid go?Annals of intensive care · 2025Review
- Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis.Physiological reports · 2025Article
- Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Plasma Volume Oscillations During Intravenous Infusion of Hyper-Oncotic Albumin.Life (Basel, Switzerland) · 2025Article
- Microcirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients.Journal of intensive medicine · 2025Article
- Diuretic responses to Ringer's solution and 20% albumin at different arterial pressures.Physiological reports · 2024Article
- The Clinical Utility of Albumin with Sequential Organ Failure Assessment (SOFA) in Improving 30-Day Mortality Prediction in Patients with Infection in the Emergency Department.Journal of clinical medicine · 2023Article
- Moderator Effect of Hypoalbuminemia in Volume Resuscitation and Plasma Expansion with Intravenous Albumin Solution.International journal of molecular sciences · 2022Review
- The glycocalyx as a permeability barrier: basic science and clinical evidence.Critical care (London, England) · 2022Review
- The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine.Veterinary journal (London, England : 1997) · 2022Review
- Ten myths about albumin.Intensive care medicine · 2022Article
- Plasma disappearance rate of albumin when infused as a 20% solution.Critical care (London, England) · 2022Review
- A call for better understanding the role of albumin in mediating VE-cadherin phosphorylation and endothelial barrier dysfunction in septic patients.Critical care (London, England) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBurn injury is associated with a long-standing inflammatory reaction. The use of albumin solutions for plasma volume support is controversial because of concerns of increased capillary leakage, which could aggravate the commonly seen interstitial oedema.
methodsIn the present open controlled clinical trial, an intravenous infusion of 20% albumin at 3 mL/kg was given over 30 min to 15 burn patients and 15 healthy volunteers. Blood samples and urine were collected for 5 h. Plasma dilution, plasma albumin and colloid osmotic pressure were compared. Mass balance calculations were used to estimate plasma volume expansion and capillary leakage of fluid and albumin.
resultsThe patients were studied between 4 and 14 (median, 7) days after the burn injury, which spread over 7-48% (median, 15%) of the total body surface area. The albumin solution expanded the plasma volume by almost 15%, equivalent to twice the infused volume, in both groups. The urinary excretion exceeded the infused volume by a factor of 2.5. Capillary leakage of albumin occurred at a rate of 3.4 ± 1.5 g/h in burn patients and 3.7 ± 1.6 g/h in the volunteers (P = 0.61), which corresponded to 2.4 ± 1.0% and 2.5 ± 1.2% per hour of the intravascular pool (P = 0.85). The median half-life of the plasma volume expansion was 5.9 (25th-75th percentiles 2.7-11.7) h in the burn patients and 6.9 (3.4-8.5) h in the volunteers (P = 0.56).
conclusionsAlbumin 20% was an effective volume expander in patients at 1 week post-burn. No relevant differences were found between burn patients and healthy volunteers.
trial registrationEudraCT 2016-000996-26 on May 31, 2016.
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Registered trials
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