Evidence map›Paper›PMID 32365945›Full record

ArticleMolecules (Basel, Switzerland)2020

Facile Synthesis of NH-Free 5-(Hetero)Aryl-Pyrrole-2-Carboxylates by Catalytic C-H Borylation and Suzuki Coupling.

Saba Kanwal, Noor-Ul- Ann, Saman Fatima, Abdul-Hamid Emwas, Meshari Alazmi, Xin Gao, Maha Ibrar, Rahman Shah Zaib Saleem, Ghayoor Abbas Chotana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Advances in Cross-Coupling Reactions.Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Saba KanwalDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.
Noor-Ul- AnnDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.
Saman FatimaDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.
Abdul-Hamid EmwasCore Labs, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID 0000-0002-9231-3850
Meshari AlazmiComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID 0000-0001-9074-1029
Xin GaoComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID 0000-0002-7108-3574
Maha IbrarDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.
Rahman Shah Zaib SaleemDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.ORCID 0000-0002-9615-4471
Ghayoor Abbas ChotanaDepartment of Chemistry and Chemical Engineering, Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore 54792, Pakistan.ORCID 0000-0003-2634-0698
Lahore University of Management Sciences · PKKing Abdullah University of Science and Technology · SAUniversity of Ha'il · SA

Funding

HIGHER EDUCATION COMMISION OF PAKISTAN NRPU-4426
6 · The paper itself

Abstract

A convenient two-step preparation of NH-free 5-aryl-pyrrole-2-carboxylates is described. The synthetic route consists of catalytic borylation of commercially available pyrrole-2-carboxylate ester followed by Suzuki coupling without going through pyrrole N-H protection and deprotection steps. The resulting 5-aryl substituted pyrrole-2-carboxylates were synthesized in good- to excellent yields. This synthetic route can tolerate a variety of functional groups including those with acidic protons on the aryl bromide coupling partner. This methodology is also applicable for cross-coupling with heteroaryl bromides to yield pyrrole-thiophene, pyrrole-pyridine, and 2,3'-bi-pyrrole based bi-heteroaryls.

Indexed as

Chemistry Techniques, SyntheticOxidative CouplingCatalysisCyclizationMolecular StructureProlinePyrroles2-pyrrolecarboxylic acidProlinePyrroles2,3′-bipyrrole5-aryl pyrrole-2-carboxylatesBorylationheteroaryl substituted pyrrolesiridium-catalyzedNH-FreeSuzuki coupling

Identifiers

PMID32365945
PMCPMC7248765
OpenAlexW3023561825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.