Evidence map›Paper›PMID 32365896›Full record

ReviewBiomedicines2020

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing.

Blair Z Johnson, Andrew W Stevenson, Cecilia M Prêle, Mark W Fear, Fiona M Wood

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 247 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed, 3 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 3 syntheses or guidelines pooled it, 475 citations in OpenAlex.

  1. Evaluation of Nile Tilapia (ACS biomaterials science & engineering · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Chemogenetic Activation of GFASEB bioAdvances · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026
    Article
  16. Enhancing Antibacterial Activity ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Article

187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Blair Z JohnsonSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Andrew W StevensonSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Cecilia M PrêleSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Mark W FearSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Fiona M WoodSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.ORCID 0000-0001-5427-6588
The University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6's diverse impact on cutaneous wound healing.

Indexed as

fibrosisIL-6skinwounds

Identifiers

PMID32365896
PMCPMC7277690
OpenAlexW3023895371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.