ReviewJournal of personalized medicine2020
Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia.
Review in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Non-invasive neuromodulation in reducing the risk of falls and fear of falling in community-dwelling older adults: systematic review.Frontiers in aging neuroscience · 2023Pooled it
- Deep transcranial magnetic stimulation in progressive supranuclear palsy: a randomized double-blind, cross-over study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Derivation of an intrinsic brain activity biomarker for the earliest prediction of cognitive decline.Scientific reports · 2026Article
- Personal and Family Perspectives Regarding Neurodegenerative Disorder Risk.Journal of community medicine & public health · 2026Article
- Combining non-invasive brain stimulation techniques and EEG markers analysis: an innovative approach to cognitive health in aging.GeroScience · 2025Review
- Fully Hyperbolic Neural Networks: A Novel Approach to Studying Aging Trajectories.IEEE journal of biomedical and health informatics · 2025Article
- EEG-based graph network analysis in relation to regional tau in asymptomatic Alzheimer's disease.Brain communications · 2025Article
- Exploring Task-Related EEG for Cross-Subject Early Alzheimer's Disease Susceptibility Prediction in Middle-Aged Adults Using Multitaper Spectral Analysis.Sensors (Basel, Switzerland) · 2024Article
- Differentiating neurodegenerative diseases based on EEG complexity.Scientific reports · 2024Article
- Monitoring synaptic pathology in Alzheimer's disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives.Molecular psychiatry · 2024Review
- Non-invasive brain stimulation in cognitive sciences and Alzheimer's disease.Frontiers in human neuroscience · 2024Review
- Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Blood-Based Proteomic Profiling Identifies Potential Biomarker Candidates and Pathogenic Pathways in Dementia.International journal of molecular sciences · 2023Article
- Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease continuum?NeuroImage. Clinical · 2023Article
- Resting-state electroencephalographic characteristics related to mild cognitive impairments.Frontiers in psychiatry · 2023Article
- Genuine high-order interactions in brain networks and neurodegeneration.Neurobiology of disease · 2022Article
- Brain Connectivity and Graph Theory Analysis in Alzheimer's and Parkinson's Disease: The Contribution of Electrophysiological Techniques.Brain sciences · 2022Review
- Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2022Review
- Task aftereffect reorganization of resting state functional brain networks in healthy aging and mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative processes of various types of dementia start years before symptoms, but the presence of a "neural reserve", which continuously feeds and supports neuroplastic mechanisms, helps the aging brain to preserve most of its functions within the "normality" frame. Mild cognitive impairment (MCI) is an intermediate stage between dementia and normal brain aging. About 50% of MCI subjects are already in a stage that is prodromal-to-dementia and during the following 3 to 5 years will develop clinically evident symptoms, while the other 50% remains at MCI or returns to normal. If the risk factors favoring degenerative mechanisms are modified during early stages (i.e., in the prodromal), the degenerative process and the loss of abilities in daily living activities will be delayed. It is therefore extremely important to have biomarkers able to identify-in association with neuropsychological tests-prodromal-to-dementia MCI subjects as early as possible. MCI is a large (i.e., several million in EU) and substantially healthy population; therefore, biomarkers should be financially affordable, largely available and non-invasive, but still accurate in their diagnostic prediction. Neurodegeneration initially affects synaptic transmission and brain connectivity; methods exploring them would represent a 1st line screening. Neurophysiological techniques able to evaluate mechanisms of synaptic function and brain connectivity are attracting general interest and are described here. Results are quite encouraging and suggest that by the application of artificial intelligence (i.e., learning-machine), neurophysiological techniques represent valid biomarkers for screening campaigns of the MCI population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.