Evidence map›Paper›PMID 32365796›Full record

ArticleMolecules (Basel, Switzerland)2020

Chemical Profiling and Cholinesterase Inhibitory Activity of Five

Raúl Moreno, Luciana R Tallini, Cristina Salazar, Edison H Osorio, Evelin Montero, Jaume Bastida, Nora H Oleas, Karen Acosta León

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Chemical Survey of Three Species of the GenusPlants (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Alkaloids ofSouth African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2021
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Raúl MorenoGroup of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.ORCID 0000-0003-0143-505X
Luciana R TalliniGroup of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
Cristina SalazarGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Edison H OsorioFacultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué, Carrera 22 Calle 67, Ibagué 730001, Colombia.ORCID 0000-0001-7636-8168
Evelin MonteroGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Jaume BastidaGroup of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
Nora H OleasCentro de Investigación de la Biodiversidad y Cambio Climático (BioCamb) e Ingeniería en Biodiversidad y Recursos Genéticos, Facultad de Ciencias de Medio Ambiente, Universidad Tecnológica Indoamérica, Machala y Sabanilla, Quito EC170301, Ecuador.ORCID 0000-0002-1948-4119
Karen Acosta LeónGrupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.
Escuela Superior Politécnica del Chimborazo · ECUniversitat de Barcelona · ESUniversidad de Ibagué · COUniversidade Federal do Rio Grande do Sul · BRUniversidad Indoamérica · EC

Funding

CYTED Ciencia y Tecnología para el Desarrollo Red BIFRENES 416RT0511
6 · The paper itself

Abstract

It is estimated that 50 million people in the world live with dementia, 60-70% of whom suffer from Alzheimer's disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the

Indexed as

AcetylcholinesteraseAlkaloidsAmaryllidaceaeBinding SitesCholinesterase InhibitorsDrug DiscoveryEcuadorGas Chromatography-Mass SpectrometryModels, MolecularMolecular ConformationMolecular StructurePhytochemicalsPlant ExtractsProtein BindingStructure-Activity RelationshipAcetylcholinesteraseAlkaloidsCholinesterase InhibitorsPhytochemicalsPlant ExtractsalkaloidsAmaryllidaceaecholinesterasesGC-MSmolecular dockingPhaedranassa

Identifiers

PMID32365796
PMCPMC7248819
OpenAlexW3022780257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.